Model pSer2448 - Anti-mTOR Antibody

Storage Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol, 0.02% sodium azide *Storage buffer may change when conjugated

Storage Temperature: -20ºC, Conjugated antibodies should be stored at 4ºC

Shipping Temperature: Blue Ice or 4ºC

Purification: Peptide Affinity Purified

Clonality: Polyclonal

Isotype: IgG

Specificity: Detects endogenous levels of mTOR only when phosphorylated at serine 2448 (pSer2448). Detects a band at ~289 kDa.

Cite This Product: StressMarq Biosciences Cat# SPC-1402D, RRID: AB_2728927

Alternative Names: FK506 binding protein 12 rapamycin associated protein 2 Antibody, FLJ44809 Antibody, FRAP1 Antibody, Rapamycin target protein Antibody, FRAP Antibody, Rapamycin target protein 1 Antibody, OTTHUMP00000001983 Antibody, EC:2.7.11.1 Antibody, FK506-binding protein 12-rapamycin complex-associated protein 1 Antibody, FKBP12-rapamycin complex-associated protein Antibody, MTOR Antibody, RAPT1 Antibody, Mammalian target of rapamycin Antibody, Serine/threonine-protein kinase mTOR Antibody, MTOR_HUMAN Antibody, FK506 binding protein 12 rapamycin complex associated protein 1 Antibody, FKBP12-rapamycin complex-associated protein 1 Antibody, dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) Antibody, RAFT1 Antibody, FRAP2 Antibody, FKBP rapamycin associated protein Antibody, FKBP12 rapamycin complex associated protein Antibody, Mechanistic target of rapamycin Antibody, FK506 binding protein 12 rapamycin associated protein 1 Antibody, Rapamycin and FKBP12 target 1 Antibody, Rapamycin associated protein FRAP2 Antibody

Research Areas: Cancer, Cardiogenesis, Cardiovascular System, Cell Cycle, Cell Cycle Inhibitors, Cell Signaling, DNA Damage and Repair, DNA Damage Recognition, DNA/RNA, Epigenetics and Nuclear Signaling, Heart, Transcription Factors / Regulators

Cellular Localization: Cytoplasm, Cytoplasmic Side, Cytosol, Dendrite, Endomembrane system, Endoplasmic reticulum membrane, Golgi apparatus, Golgi Apparatus Membrane, Golgi Membrane, Lysosomal Membrane, Lysosome, Membrane, Microsome Membrane, Mitochondrion, Mitochondrion outer membrane, Neuronal Cell Body, Nucleoplasm, Nucleus, Peripheral membrane protein, Phosphatidylinositol 3-Kinase Complex, PML body, Torc1 Complex, Torc2 Complex

Accession Number: NP_004949.1

Gene ID: 2475

Swiss Prot: P42345

Scientific Background: an atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.