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Boston Pharmaceuticals
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  5. Boston - Model BOS-342 - Bispecific ...

Boston - Model BOS-342 - Bispecific Antibody

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BOS-342 is a bispecific antibody comprised of an anti-GPC3 antagonistic antibody linked to a 4-1BB (CD137) agonistic anticalin protein.

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  • BOS-342 binds with high affinity to cells expressing human GPC3 and 4-1BB.
  • It is designed to accumulate in GPC3 positive tumor cells where it will activate 4-1BB on the tumor infiltrating immune cells.
  • BOS-342 has the potential to be active in HCC and other solid tumors expressing GCP3.