Celularity - Model CAR-T - Chimeric Antigen Receptor T Cells
Chimeric Antigen Receptor T cells (CAR-T) are genetically engineered T cells that are modified to express an artificial T cell receptor on their surface that binds and targets cancer proteins in an HLA-independent manner.
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Unlike adult peripheral blood mononuclear cell derived T cells, placental-derived CAR T cells are mostly naïve (CD45RA+), expand readily ex vivo, express markers of stem cell memory, and have lower expression of effector or exhaustion markers, allowing for greater proliferative potential of these cells in vivo.
P CAR-T cells are in development for the treatment of hematological and solid tumor indications. We have demonstrated that pCAR-T cells exhibit potent anti-tumor activity both in vitro and in vivo.
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