Pharmigene -Model CYP2C19*2 & *3 -Detection Kit (RUO)
FromPharmigene, Inc.
Clodpgrel, an antiplatelet agents is indicated for the reduction of thrombotic events as follows: Recent MI, Recent Stroke or Established Peripheral Arterial Disease. For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, Clopidogrel has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.
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CYP2C19*2 & *3 Detection Kit (RUO)
- Pharmacokinetic and antiplatelet tests of the active metabolite of Clopidogrel show that the drug levels and antiplatelet effects differ depending on the genotype of the CYP2C19 enzyme.
- The following represent the different alleles of CYP2C19 that make up a patient`s genotype:
- The CYP2C19*1 allele has fully functional metabolism of Clopidogrel
- The CYP2C19*2 and *3 alleles have no functional metabolism of Clopidogrel. These two alleles account for most of the reduced function alleles in patients of Caucasian (85%) and Asian (99%) descent classified as poor metabolizers.
- In March 2010, the US FDA put a black box warning on Plavix to make patients and healthcare providers aware that CYP2C19 poor metabolizers, representing up to 14% of patients, are at high risk of treatment failure and that testing is available.
- Pharmigene, Inc. conducted in development CYP2C19*2 & *3 Detection Kit, and sequencing methods for product validation.