Feldan Therapeutics Technology

Rationally designed from natural cell-penetrating peptides and endosomal leakage domains, the Feldan Shuttle is a short peptide that successfully circumvents endosomal entrapment. The Shuttle was engineered to perform highly effective and safe cytoplasmic delivery of multiple types of therapeutics, ranging from small molecules to proteins. Using our technology, we deliver biological compounds for which there are no other efficient delivery methods.

Membrane Interaction
The Shuttle interacts strongly with the membrane to initiate the permeabilization process.

Endosomal Leakage
While the Shuttle remains in the membrane, the free therapeutic compound translocates to the cytoplasm.

The Feldan Shuttle provides a unique way to deliver therapeutic compounds inside cells and is allowing the development of next-generation therapies.

• Peptide-based
• Fast degradation
• No toxic metabolites
• Safe for in vivo use
• Delivery of peptides and proteins
• Circumvent endosomal entrapment
• Performs fast delivery on multiple cell types, ex vivo and in vivo

The Feldan Shuttle allows untapped and highly specific therapeutics compounds to access intracellular pathways that can be targeted for therapeutic interventions. The versatility of the technology translates into multiple strategies to correct diseases:

Repressing Pathogenic Pathways
Having access to the intracellular space allows the targeting and correction of dysregulated proteins and signalling pathways associated with diseases.

Supplying Missing Proteins
The Feldan Shuttle allows the development of a new generation of therapies for diseases caused by the absence of intracellular proteins.

Rewriting Impaired Genes
The Feldan Shuttle allows the delivery of gene-editing nucleases in their active protein form. This allows precise and safe correction of impaired genes.