MammaTyper - Model ERBB2 - Gene Biomarker for Human Epidermal Growth Factor Receptor 2

ERBB2 is the name of the gene for human epidermal growth factor receptor 2 (HER2). This receptor is a cell surface protein which belongs to the family of epidermal growth factor receptors. ERBB2 activation stimulates cell proliferation and inhibits programmed cell death. ERBB2 has an important role in Breast Cancer. About 20 % of all Breast Cancers show an overexpression of this receptor, which is associated with poor prognosis and clinical outcome. Patients with an ERBB2 overexpression can benefit from an anti-HER2 therapy, where antibodies target the receptor and inhibit its function.