Heparosan
HTL is developing Heparosan, a promising raw material of non-animal origin forthe design of innovative medical devices. OPENING NEW OPPORTUNITIES FOR MEDICAL DEVICES. Building on the success of Hyaluronic Acid, HTL now brings Heparosan to the market, Heparosan is a naturally occurring biopolymer with a structure and basic functionalities that are very close to those of Hyaluronan, With its own specific characteristics and additional functionalities, Heparosan opens up opportunities for innovation in medical devices, when used alone or in combination with Hyaluronic Acid, other biomaterials or actives,
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Growing the Range of Glycosaminoglycans Biopolymers
Heparosan is an endogenous Glycosaminoglycan, known as the natural bioprecursor of heparin in mammals. HTL can offer high molecular weight Heparosan of non-animal origin and high purity thanks to its highly controlled manufacturing process performed in its pilot-scale manufacturing facilities located in France.
Under exclusive license, HTL has been using two patent families protecting the production of heparosan by fermentation, and has developed:
- a specific strain able to produce higher molecular weight Heparosan,
- a proprietary manufacturing process enabling the polymers' molecular weight to be monitored,
Today, HTL can produce Heparosan with a Molecular Weight from 20 kDa to 2MDa. HTL is also your partner for the development of tailor-made functionalized derivatives of Heparosan such as Heparosan sulfate.
Opportunities In Medical Products
Heparosan has potential applications in ophthalmology, orthopedics, aesthetics and dermatology, and for the coating of medical devices, Heparosan and Heparosan derivatives are also good candidates for high-quality biomaterials, gels and scaffolds for tissue engineering, as well as for serving as a drug delivery vehicle,
Beyond its visco-elastic and moisturizing properties, Heparosan is also being investigated for its biological properties, including anti-inflammatory properties.
AESTHETICS
With its lower degree of crosslinking (when crosslinked) and potentially higher persistence, Heparosan has possible applications in dermal fillers.
RHEUMATOLOGY
Heparosan has a potentially higher durability, which could demonstrate interest for intraarticular injections for the symptomatic treatment of osteoarthrosis of the knee and other types of arthrosis.
OPHTHALMOLOGY
In eye drops for the symptomatic treatment of dry eye as well as other solutions for eye treatment, Heparosan has potential benefits in reducing frequency of use
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