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Human Brachiocephalic Artery Endothelial Cells: HBcAEC
Human Brachiocephalic Artery Endothelial Cells (HBcAEC) along with human aortic (HAOEC), carotid artery (HCtAEC), coronary artery (HCAEC) and subclavian artery (HScAEC), all from Cell Applications, Inc., have been used to demonstrate that not only blood vessels from different tissues are highly heterogeneous, they also interact differently with leukocytes during the inflammation response. The authors further showed that differential N-glycosylation of commonly expressed vascular adhesion molecules may be responsible for this heterogeneity, as well as for modulation of signaling under resting and activated inflammatory conditions. This also explains why specific vascular beds may be more or less susceptible to particular diseases or stimuli.
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Importantly, if cells from different sources were used, these results could not be convincingly validated due to a number of uncontrolled variables, such as age, race, genetic variability or life style choices of the donors. To eliminate the donor-to-donor variability, the scientists took advantage of the great variety of primary cells offered by Cell Applications, including the option of ordering a panel of endothelial cells obtained from different vascular beds of the same donor!
Because of the complex heterogeneity that exists not only between different donors, but even between different vascular beds in the same individual, it would be prudent to confirm any new findings on primary cell lots coming from several different origins.
Tissue: Normal health human brachiocephalic artery
QC: No bacteria, yeast, fungi, mycoplasma, virus
Character: Factor VIII-related Ag, DiI-Ac-LDL uptake
Bioassay: Attach, spread, proliferate in Growth Med
Cryovial: 500,000 HBcAEC (2nd psg) frozen in Basal Medium w/10% FBS, 10% DMSO
Kit: Cryovial frozen HBcAEC (3012-05a), Growth Medium (212-500), Subculture Rgnt Kit (090K)
Proliferating: Shipped in Tsfr Med, 3rd psg (flasks or plates)
Doublings: At least 12
Applications: Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.