Episkin
SkinEthic -Â Model RHE-LC - Human Epidermal Model Langerhans Cells
FromEpiskin
The SkinEthic RHE-LC model is a standard epidermal model in which Langerhans cells progenitors have been integrated. During the tissue reconstruction, these immature cells have differentiated into antigen-presenting Langerhans cells expressing the specific marker CD207 (langerin). They are mostly located and evenly spread within the supra-basal epidermal layer. The SkinEthicâ„¢ RHE-LC model is therefore expected to be a useful tool for skin immune response studies.
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immune response
antigen present
antigen presentation
epidermal layer
dermal epidermal
epidermal cell
collagen
antigen expressed
antigen expression
collagen type
Specific markers
Langerhans cells markers :
- CD207 langerin (See picture)
- Birbeck granules (See picture)
- CD1a
- CD80
- CD86
- CCR7
Differentiation markers:
- Filaggrin
- Involucrin
- Loricrin
- Keratin 10
- Keratin 5
- Presence of different epidermal classes of lipids comprising ceramides
Dermal-Epidermal junction markers
- Type IV collagen
- Laminin V
- Alpha6Beta4-integrin
- BP antigen
Proliferation markers
- Ki67