Hyaluronidase Technology

Solid tumors are complex organ-like structures consisting of cancer cells, vasculature, and tumor matrix. This dense extracellular matrix, also known as stroma, hampers the intratumoral accessibility of chemotherapy, antitumor immune cells, and oncolytic viruses. Our viruses are “armed” with a soluble version of human sperm hyaluronidase (hyal) PH20 to enhance virus spreading and help the actions of chemotherapy and the immune system.