DxTerity -IFN-1 Test Kit for Lupus
DxTerity’s IFN-1 Test uses a simple fingerstick blood collection conducted at your doctor`s office. Measure your IFN-1 levels and know your risks for SLE disease progression. Take back control of your health.
- Measures 4 messenger RNAs (mRNAs) associated with Type 1 Interferon (IFN-1) activity
- Prognostic marker for increased risk of severe Systemic Lupus Erythematous (SLE)
- Prognostic marker for increased risk of developing Lupus Nephritis
- Available through your rheumatologist
Type-1 Interferon (IFN-1) activity is central to how your body defends itself against viruses and pathogens, however persistent increased activity has been shown to play a central role in Systemic Lupus Erythematosus (SLE) disease development and progression.1 The IFN-1 immune pathway is a therapeutic target13,14 for drugs such as recently approved anifrolumab.
- More than 50% of SLE patients overexpress IFN-1, and this overexpression has been linked to increased disease severity.5,6,11
- IFN-1 test has been shown to be a key prognostic marker for SLE patients with IFN-1 high patients having a 3X increased risk of developing lupus nephritis.4
- IFN-1 High SLE patients may be at a greater risk of complications during pregnancy, including the potential for preeclampsia.7
The IFN-1 test measures the relative expression of 4 mRNAs associated with Type-1 Interferon activity. These mRNA results are used to calculate an IFN-1 score, which is evaluated against an established threshold to determine if a patient is Interferon High or Interferon Low.
The DxTerity IFN-1 Test will determine if the blood sample submitted for testing reports High or Low Type-1 Interferon gene expression levels. This information provides a baseline value of IFN-1 activity and, in conjunction with clinical assessment and other laboratory tests, may provide information to help your healthcare provider determine appropriate treatment options to help you now and in the future as more therapeutics become available.