NanoString - Model GeoMx - Immune Pathways Panel

The Immune Pathways panel contains 84 targets plus controls designed for broad coverage of the tumor and tumor microenvironment. GeoMx RNA assays contain in situ hybridization (ISH) probes conjugated to unique DNA indexing-oligonucleotides via a UV-photocleavable linker. After region of interest (ROI) selection on GeoMx DSP and UV cleavage of the oligonucleotides, each DNA oligonucleotide is recognized by a unique Reporter probe that contains a fluorescent barcode. Reporter probes are imaged and counted by the nCounter® Analysis System to provide a direct, digital readout of spatially resolved RNA expression.

• Curated content designed for immuno-oncology research
• Includes tumor and tumor microenvironment coverage plus the Tumor Inflammation Signature (TIS)
• Pre-validated in multiplex format for use in human FFPE or fresh frozen tissue
• Compatible with RNAscope® and antibody morphology markers for tissue imaging
• Customizable with up to 10 additional targets of interest
• For use with nCounter readout and compatible with DSP Data Center

The GeoMx Immune Pathways panel is designed to profile key aspects of the tumor and tumor microenvironment biology.

• Profile the global immune response
• Assess microenvironment immune activity
• Quantify tumor reactivity
• Measure the 18-gene Tumor Inflammation Signature known to be associated with response to PD-1/PD-L1 inhibitor pathway blockade

Accompanying Morphology Marker Kits are available for tissue visualization and ROI selection.