OMass Platform

• Faithful to the native ecosystem. We use proprietary biochemistry to preserve downstream partners, lipid interactions and endogenous regulatory molecules.
• Biology distilled to its essential elements. We use our patent protected native mass spectrometry (MS) technology to measure the physical interactions that drive biology.
• The full spectrum of pharmacology. We leverage custom chemistry enabled for MS to interrogate binding and multiple discrete biological outcomes rationally and systematically.

Combining the biological richness of a cell-based assay with the precision of a cell-free method allows us to go after the best targets. We can:

• Unambiguously link binding and function driving smart lead optimization and avoiding blind alleys from indirect effects
• Capture a broad range of affinities identifying low affinity starting points at challenging targets that are lost in other assays through our combination of native, precise measurements
• Unlock novel biology by identifying binders without the filter of an activity threshold; important for targets driving more than one biologically relevant outcome
• Identify natural allosteric sites from endogenous regulatory molecules and exploit these for drug discovery, critical when the orthosteric site is intractable to small molecules