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Affimed GmbH
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  5. Affimed - Model ROCK - Redirected ...

Affimed - Model ROCK - Redirected Optimized Cell Killing Platform

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The proprietary ROCK platform enables a tumor-targeted approach that can be tailored across hematological and solid tumors. The ROCK (Redirected Optimized Cell Killing) platform allows for a modular approach to generating customizable ICE (innate cell engager) molecules. High-affinity ICE (innate cell engager) molecules, which are created using the ROCK platform, are capable of bivalent NK-cell binding via CD16A without inducing nonspecific NK-cell activation or cell fratricide.

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natural killer cell
tumor targeting
solid tumor
cancer cell
cancer treatment
hematologic
hematology

The bivalent interaction of our ICE® (innate cell engager) molecules with CD16A increases NK-cell activation and antitumor activity. ICE® (innate cell engager) molecules with a tetravalent, bispecific structure may stimulate increased tumor-cell killing in vitro relative to Fc-enhanced IgG antibodies.

Versatile Platform

Tailoring tetravalent, bispecific ICE® (innate cell engager) molecules to specific indications.

Strong Engineering

Proven record in building potent and stable ICE® (innate cell engager) molecules.

Proprietary Target

Allows for specific CD16A-targeting.

publications and posters

See our wealth of clinical literature (2009-2021).

pipeline

Explore our growing pipeline of ICE® (innate cell engager) molecules and combination products.

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Join the next revolution in cancer treatment.