Remplir - Nerve Wrap
Every year, millions of people suffer peripheral nerve injury as the result of motor vehicle, sporting or work-related incidents. Nerve injuries result in pain, numbness, burning or tingling, or complete paralysis of the affected limb. Many people with nerve injuries are unable to work or participate in their favourite sport, and even simple things like getting dressed or making a cup of coffee becomes difficult. Surgery to repair damaged nerves is delicate and complicated, and only successful some of the time. Orthocell’s Remplir™ collagen membrane assists in rejoining severed or severely damaged peripheral nerves to restore function and sensation.
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Adrian’s Story
Watch the video for more on Adrian’s story.
Early results from Orthocell’s clinical trial using Remplir™ in nerve repair (1) were extremely encouraging. The first patients to complete the trial experienced an 83 % improvement in muscle power and regained feeling in their limbs with no pain.
The encouraging early results from the trial gave Dr Alex O’Beirne, the trial’s Principal Investigator, the confidence to attempt nerve repair on more complex injuries. The most recent results from the first 12 patients have validated these early findings. At 12 months post-treatment:
- 96% of nerve repairs restored voluntary movement to previously paralysed muscles and
- 86% of patients who required prescription medication (including opioid-based medications) for chronic nerve pain were able to significantly reduce or stop using them.
Almost half the nerve repairs (11 of 25) were performed in three quadriplegic patients with partial or total loss of movement in both arms and legs. The results have been significant, with 73% of nerve repairs resulting in meaningful recovery of muscle function.
More information on Remplir™’s nerve regeneration trial can be found here.
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CTRN12616001157460 Case Series Study: Surgical Repair of Peripheral Nerve Injury with Remplir™ Collagen Scaffold.
Nerve repair with Remplir™ does not require the use of sutures to hold the membrane in place (see Remplir™ surgical procedure below). Tensionless repair is highly desirable in nerve reconstruction for several reasons, but primarily because it reduces the risk of additional damage to the nerve, and it reduces the time needed to complete the surgery. Orthocell designed Remplir™ with handling characteristics to assist surgeons perform complex reconstructive surgical procedures with tensionless repair.
Remplir™ Surgical Procedure
1. Peripheral Nerve Injury
Crushed peripheral nerve after traumatic injury to limb
2. Preparation of Repair Site
Damaged section of nerve is removed and the ends are brought to repair site without tension
3. Microsurgical Repair with Remplir™
Remplir™ is wrapped around nerve and secured, forming a sealed conduit
4. Remplir™ guides and supports nerve repair
New nerve fibres reconnect
5. Healed nerve
Healed nerve restores function and sensation to affected limb
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