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Locus - Model CRISPR-Cas3 - Synthetic Biology
Locus is the world’s leading developer of products based on CRISPR-Cas3 systems. CRISPR evolved as a bacterial immune system, which protects bacterial cells from invading viruses. Cas3 is a powerful exonuclease that shreds the DNA of targeted bacterial cells beyond repair, leading to rapid and predictable cell death. We use Cas3 to dramatically increase the potency of crPhage compared to their natural phage counterparts where we ensure that every infection event results in the death of the bacterial cells.
In the pursuit of developing crPhage Locus has become the world’s leading experts in engineering bacteriophage.
The very nature of engineering CRISPR-Cas3 into the genomes of bacteriophage has forced us to become intimately familiar with bacteriophage genomics and phenomics. This enables us to manipulate traits that natural bacteriophage may or may not have, therefore allowing us to enhance desirable attributes or diminish unfavorable characteristics. Furthermore, we are leveraging the bacteria-bacteriophage relationship to precisely deliver and manufacture biotherapeutics within the human body.
