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Alfa Chemistry - Active Pharmaceutical Ingredients - Methotrexate

Methotrexate, one of the earliest cancer chemotherapy agents, which is extensively used in the treatment of cancer, including breast cancer, leukemia, lung cancer, lymphoma, osteosarcoma and so on. The efficacy of methotrexate mainly due to its inhibitory effect on dihydrofolate reductase (DHFR)[1]. DHFR catalyzes the conversion of dihydrofolate to the active tetrahydrofolate that is needed for the synthesis of nucleoside thymidine. Nucleoside thymidine is critical for DNA synthesis. In other words, methotrexate can inhibit the synthesis of DNA in cancer cells.