Cell Therapy Services
Application of RNAscope™ ISH in our Good Clinical Laboratory Practices (GCLP) compliant Professional Assay Services laboratory. RNAscope is the only assay that can specifically detection engineered cell therapies and measure target engagement in intact human tumor biopsies.
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Details
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Clinical trial cell therapy multiplexed analysis:
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Cell therapy detection with probes targeting viral or synthetic UTRs), e.g., WPRE
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Target engagement assays with probes to cytokines, e.g., IFNG,
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T cell recruitment assays by IHC/IF for detection of CD3, CD4, or CD8-positive T cells.
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Preclinical cell therapy development
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Cell therapy detection and activation assays in animal models
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Viral vector copy number (VCN) assays
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DNA in situ hybridization measurements of viral copy number in cell therapy product
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Safety assessment
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Viral vector DNA and RNA ISH assays to rule out role in patient secondary tumors
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