POP Biotechnologies, Inc. (POP BIO)
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Effective Anti-tumor Treatment Services
Nanograms of peptide reverse established and metastatic tumor rowth in TC-1 tumor model. Other cancer models show synergy with checkpoint blockade inhibition and other anti-tumor treatments.
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Find the needle in the haystack
- SNAP is ideal for multivalent immunization.
- Short peptide microlibraries with SNAP enables finding functional neoepitopes from candidate lists.
- SNAP vaccines are functional even when 59 irrelevant peptides are mixed with a single functional neoepitope.
Make self-antigens immunogenic
- Self-antigens typically are poorly immunogenic
- SNAP allows unbiased determination of mutated epitopes with enhanced function using a two-step microlibrary screening method
- Success rate of enhanced epitope selection is ~50%. 10 identified so far against 3 target murine epitopes (Trp-2, AH1, WT1).
Path for human testing
- CoPoP made by POP BIO produced under GMP at 2.5M dose scale. Other components obtainable under GMP.
- CoPoP GLP toxicity report available.
- CoPoP is part of EuCorVac-19, tested in a 280 person ph1/2 trial.
- Testing framework for human epitopes