MedGenome - BCR Sequencing Service
From NGS Services
It is estimated that there are approximately 1010–1011 B cells in a human adult. A BCR is composed of two identical heavy chains generated by recombination of V, D and J segments and two identical light chains generated by recombination of V and J segments. Human BCRs undergo recombination at these variable regions, generating a large diverse receptor profile for each cell. Utilizing targeted next-generation sequencing of these variable regions, can provide deeper insights into B-cell differentiation, BCR somatic hypermutation, class switching, and antigen specificity. Major applications of BCR repertoire profiling include diagnostic biomarker discovery, tracking known repertoire sequences and disease diagnosis.
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Service Highlights
- Support with experimental design and selection of appropriate application depending on analysis requirements, quantity and quality of input
- Higher sensitivity in detecting low frequency BCRs including samples with low input
- End-to-end solutions for extraction, sample QC, library preparation, sequencing and bioinformatics analysis
- Accurate representation of expressed BCRs vs non-functional BCRs with improved ability to call novel and low frequency clones
BioFX BCR Repertoire Analysis
- Streamlined pipeline for fast & scalable analysis
- Customized reporting
- Interactive reports
- Publication-ready figures
- Improve data interpretation with support from MedGenome's team of experts
Ordering and Data Delivery
MedGenome's customer portal allows for easy sample submission and sample tracking during lab processing. Data QC, raw data and interactive analysis reports are delivered securely through customer portal.
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