MedGenome Inc. services

Single cell analysis has become a gold standard application in both basic as well as translational research. Several approaches are now available that capture the maximal transcript diversity in a given cell and allowing for multi-model analysis strategies to generate meaningful insights. MedGenome has adopted several commercially available platforms for single cell analysis.

TCR profiling holds great potential not only for understanding the mechanisms of development of the normal immune response, but also in providing insights into disease mechanisms and development of new therapeutics and treatment modalities in infectious diseases, autoimmunity and in immuno-oncology. However, identification of all potential clonotypes in a diverse repertoire of TCRs requires sensitive methods of detection. Next-generation sequencing (NGS) technologies have recently enabled accurate detection of TCRs, and in combination with other assays, allow for the assessment of the TCR repertoire in patients which in turn is a proxy for patient prognosis and response. At MedGenome, we provide RNA based TCR repertoire profiling services for bulk and single cell analysis.

Single cell analysis has become a gold standard application in both basic as well as translational research. Several approaches are now available that capture the maximal transcript diversity in a given cell and allowing for multi-model analysis strategies to generate meaningful insights. MedGenome has adopted several commercially available platforms for single cell analysis.

A comprehensive suite of bioinformatics services for NGS data analysis encompassing a wide range of applications including genomics, transcriptomics, single cell genomics, immune profiling, genome assembly and annotation and more. Our team of experts combined with our advanced reporting have resulted in over 200 scientific publications in high-impact journals. Let us help you get the most out of your data.

Detailed RNA specific QC reports. Differential expression analysis. Pathway enrichment analysis. Fusion and splicing event analysis with interactive genome browser to visualize results. Proprietary tumor microenvironment analysis.

Profiling the Tumor Microenvironment: Using a genomics based approach to analyze the tumor microenvironment can provide unique insights beyond IHC and FACS methods. OncoPeptTUME deeply interrogates RNA-Seq data sets to produce high resolution mapping of the tumor microenvironment using proprietary cell type specific gene expression signatures. OncoPeptTUME provides a critical assessment of the inflammatory microenvironment that modulates T-cell infiltration and its anti-tumor activities to enable better prediction of treatment response and efficacy.

Antibody discovery is an important component for early-stage research studies, diagnostics, and therapeutics. Hybridoma technology has been the forefront tool in generating monoclonal antibodies but is time consuming and costly. MedGenome’s proprietary HitMab platform now enables researchers to identify antigen-specific antibodies in less than 6 months’ time.