Natural Killer (NK) Cell Media, Instruments, and Reagents for Cell Therapy
Natural killer (NK) cells are innate lymphocytes that kill virally infected or malignant cells. Unlike T cells, NK cells function in an antigen independent manner, responding to anything they perceive as 'non-self', including malignant cells. NK cells are an attractive allogeneic immune modulator, as they have a well-known safety profile and lack the potential to cause graft-vs-host disease, a risk associated with CAR-T cell immunotherapy. This makes them an attractive cell type for development of off-the-shelf immunotherapies (Front Immunol 13:1869 (2018)).
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Services Overview
Pre-clinical and clinical studies have demonstrated safety and efficacy of allogeneic NK cells against various malignancies—both hematological and solid tumors, without the need for strict HLA-matching. Several clinical trials are currently ongoing which use NK or CAR NK cells as off-the-shelf allogeneic therapeutics. However, many NK cells are needed in order to infiltrate solid tumors effectively. Generation of sufficient cell numbers for off-the-shelf allogeneic translational, cancer immunotherapy requires efficient scale-up culture conditions.
At Thermo Fisher Scientific, we have developed Gibco Cell Therapy Systems (CTS) products across the cell therapy workflow to facilitate the transition from discovery to commercial manufacturing. CTS reagents are manufactured in conformity with GMP for medical devices, 21 CFR Part 820, and follow USP<1043> and Ph Eur 5.2.12. They are available at commercial scale with a high degree of qualification, traceability, and regulatory documentation, to help you transition your cell therapy to the clinic with confidence.
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