Preclinical Drug Development
Long before your team will experience commercial success with your brand name drug, preclinical drug development activities take center stage. By the time you submit your investigational new drug (IND) application you’ll want to retire as many risks as possible and have confidence that your experimental drug will have its intended effects on the intended to treat population (ITT). Getting a strong drug candidate to the IND phase is a major step on your path to commercial success.
Leverage ClearLight for your Preclinical Drug Development
Preclinical drug developers in academic and commercial environments work with ClearLight to gain an early advantage in their quest to advance effective therapeutics. Preclinical researchers leverage our expertise with CLARITY tissue clearing, thick tissue immunostaining, and Tru3D® tissue analysis to gain a better understanding of the tissue microenvironment.
The CLARITY protocol enables researchers to work with larger tissue volumes to maintain tissue integrity and minimize the potential cell destruction associated with 2D thin section FFPE sample preparation.
Researchers who work with ClearLight, See More Biology
Imaging biomarkers in three dimensions reveals novel insights unobtainable with 2D FFPE and other technology:
- Understand the spatial relationships in the tissue microenvironment
- See where apoptosis and/or necrosis may be occurring
- Verify drug delivery to the intended tissue region
- Trace vasculature through the tissue
- Draw insightful conclusions leading to new and better questions
CLARITY Beyond the Brain
Chances are, ClearLight has worked with your research tissue type. ClearLight has evaluated numerous normal and diseased tissues. Our scientists have taken CLARITY beyond the brain to include organoids, eye, lymph nodes, skin, calcified tissues (bone and teeth), kidney, breast, colon, lung, pancreas, liver, tonsil, and other human and animal tissues.
ClearLight pushes the envelope of tissue clearing with continued innovation of its products and services.
- More biologically representative analysis of drug mechanism of action by analyzing 3D tissue
- Deep expertise and intellectual property for CLARITY Tissue Clearing
- Experts at thick tissue antibody staining using a library of optimized antibodies
- Tru3D Tissue Analysis allows pathologists and drug researchers to see more biology than is currently possible with traditional 2D FFPE thin section methods
- CLARITY-based tissue clearing services offer 10X more contiguous and more meaningful data as compared to current gold standard 2D FFPE thin-sections
- Proprietary AI software to analyze 3D images (under development)
- CLARITY allows a tissue sample to be rendered optically clear, retain its three-dimensional integrity and allows for tissue staining and re-interrogation multiple times.
ClearLight is a collaborative research organization. Unlike traditional contract research organizations that want to put you in a box, we listen and co-design an approach that answers your research question. Not all research follows a straight path. As our service engagement unfolds, new questions often arise.
Customer reviews
No reviews were found for Preclinical Drug Development. Be the first to review!