Administration Of Drug Articles & Analysis
89 articles found
Liposomes, spherical vesicles composed of one or more phospholipid bilayers, have garnered significant attention in the field of drug delivery due to their unique properties. These nanocarriers offer a promising approach to overcome challenges associated with traditional drug administration, enhancing therapeutic efficacy while minimizing side ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
HCP (Host Cell Proteins) residual detection is a key quality control step in the field of biopharmaceuticals, aiming at ensuring that the proteins of the host cells used for producing therapeutic proteins in any cell-based production system are maintained at acceptable low levels in the final drug product.ImportanceHCPs are impurities during the production process, which may ...
In such a scenario, if a patient does not react to a drug, it may be decided to change the drug or dosage. Some therapeutic areas and scenarios like immuno-oncology, multi-arm trials also add new levels of complexity to clinical trials. ...
ByClinion
Successful AAV formulation demands understanding factors such as administration routes and organ-specific distribution, stability, vector aggregation, manufacturing-related impurities, and vector-host interactions. Enhancing cGMP Capacity: A Prerequisite for Efficient Therapies To accompany this technical transformation, expansion in cGMP capacity is a necessity. cGMP represents ...
It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material available on the market. ...
Ordinary nanogels will swell when absorbing water, and their drug administration and subsequent release behavior will be single. Environmentally responsive nanogels will swell or dissolve when exposed to different environments, and their administration and subsequent release behavior will be more intelligent. ...
Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and subcellular localization.Currently, the US Food and Drug Administration (FDA) and the European Medicines Agency ...
Transdermal drug delivery system is a type of drug formulation that is absorbed into the body circulation through capillaries at a certain rate through the skin to produce drug effects. Transdermal drug delivery systems allow the drug to continuously diffuse through the skin, penetrate and absorb into the blood ...
Based on the needs above, current ionizable cationic lipids approved by Food and Drug Administration, such as DLinMC3-DMA (MC3), ALC-0315, and SM-102, do not meet the requirement of "biodegradable". ...
Over the years, several innovative drug delivery systems have been developed to improve drug efficacy and patient outcomes. ...
Factors Considered When Determining Shelf Life Expiration Dates Shelf life expiration dates are vitally important to ensure medical devices are safe to use. The Food and Drug Administration (FDA) requires product labels to indicate an expiration date if a certain component is not useful past a certain date. ...
Regulatory Requirements and Standards The Federal Drug Administration (FDA) oversees medical device package testing in the United States. ...
Various administration routes have been used to achieve site-specific delivery of LNP, including oral administration, inhalation, and local injection (intramuscular, intratumoral, and intracerebral injection). 1) Oral administration is a widely used, convenient, and well-established route of administration. ...
These innovative patches provide a minimally invasive and painless alternative to injections while ensuring precise and controlled drug administration. In this article, we will explore various types of microneedle patch technologies, including phase-transition microneedle patches, hydrogel microneedle patches, solid microneedles, hollow microneedles, coated ...
These characteristics enable better drug spreading over the skin, resulting in enhanced drug absorption. ...
This new approach to treatment incorporates patient perspectives into drug development. A key benefit is the keener focus on convenience and safe drug administration. ...
Most of the clotting factors used for the treatment are obtained from human plasma however, in 1992 the U.S. Food and Drug Administration first time approved a genetically engineered recombinant factor VIII. ...
Renata Marchette working within the National Institute on Drug Abuse Intramural Research Program provides a model example of the how plethysmography can be used to assess ventilatory behavior changes that occur with opioid administration. ...
Limiting Residual Host Cell DNA: The World Health Organization (WHO), U.S. Food and Drug Administration (FDA), and European Pharmacopoeia recommend risk assessment based on cell matrix properties and product use. ...