cardiometabolic Articles
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Rationale, Design, and Methodological Aspects of the BUDAPEST-GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions)
Abstract The heritability of coronary atherosclerotic plaque burden, coronary geometry, and phenotypes associated with increased cardiometabolic risk are largely unknown. The primary aim of the Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions (BUDAPEST-GLOBAL) study is to evaluate the influence of genetic and environmental factors on the ...
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Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: a classical twin study
Abstract Background/objectives: Various adipose tissue compartments play an important role in the development of cardiometabolic diseases. The quantity of different fat compartments is influenced by genetic and environmental factors. The aim of our study was to evaluate the magnitude of genetic and environmental effects on epicardial, subcutaneous and visceral adipose tissue (EAT, SAT and ...
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Akkermansia muciniphila - Preclinical studies
A large body of evidence suggests that Akkermansia muciniphila may help protect against specific metabolic disorders and cardiometabolic risk factors associated with a low-grade inflammatory status. Indeed, preclinical studies performed in diet-induced obese mice revealed very interesting beneficial effects linked to the daily oral administration of Akkermansia muciniphila. Giving the ...
By A-Mansia
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Special Genes May Affect the Level of Lipopolysaccharide in the Body’s Blood
Transfer of lipopolysaccharide from gram-negative bacteria into the systemic circulation of the body leads to the development of endotoxemia, which is detected in cardiometabolic diseases such as cardiovascular disease and obesity in addition to acute infections. Lipopolysaccharide is a virulence factor produced by bacteria, which often triggers systemic inflammation through the body's ...
By CD BioGlyco.
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Meet Nuritas, the bitoech using AI to identify the next generation of intelligent ingredients
As part of our quick fire questions series – or QFQs – we spoke to Dr. Andy Franklyn-Miller, Chief Medical and Innovation Officer at Nuritas about intelligent ingredients, explaining peptides and proving an AI model in life science. There is a lack of innovation within ingredients in food, many have been discovered decades ago, mostly with cost, taste and texture in mind. However as ...
By Nuritas Ltd.
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Powering Up Peptide Discovery with AI
Nuritas has recently published the results of two clinical studies on their next-generation ingredient PeptiStong™. Identified within fava beans, with self-affirmed GRAS and Health Canada approval, Peptistrong™ contains cell-signalling peptides which, when compared against milk proteins, were found to improve the rate of muscle protein synthesis during recovery. In this New Protein ...
By Nuritas Ltd.
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In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome
Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. We ...
By VeriSIM Life
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