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Clinical Outcome Articles & Analysis
50 articles found
Ischaemic heart diseases continue to be a major global health concern and a leading cause of death. To develop more effective treatments, it is essential for researchers to work with animal models that closely replicate human cardiac physiology. In a notable step forward, Pius et al. present a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which ...
Key Benefits of Using Radiopaque Markers in Clinical Settings In the world of clinical settings, precision is key. ...
Blood flow analysis plays a crucial role in clinical medicine, particularly in cardiovascular and ophthalmic care. ...
FeNO monitoring applications have been acknowledged globally in other well-recognised clinical guidelines, including the American Thoracic Society (ATS) and the Global Initiative for Asthma (GINA). Not acknowledged in previous asthma clinical guidelines by NICE or BTS/SIGN, a recommendation has been made to include FeNO evaluations as part of regular yearly ...
Clinical trials are the backbone of modern medicine, responsible for bringing innovative, safe, and efficient treatments to market after rigorous testing and evaluation. ...
HCP in therapeutic protein processes and its effects In the production process of therapeutic proteins based on various animal cell culture , all impurities need to be reduced to acceptable levels in order to improve product purity and meet the needs of clinical research. Among them, host cell protein (HCP) is an important impurity. ...
One of the main benefits of using Nuvonis’ fully tested GMP Vero cells is the unparalleled speed towards clinical trials. A case example from one of our customers, hVIVO: First contact with Nuvonis in July 2020, due diligence, contracting, provision of GMP Vero cells and protocols, as well as full documentation Production of GMP material in ...
ByNuvonis
REAL is a phase 2a open-label study to assess preliminary safety, tolerability, and effect on clinical outcomes as well as neurodegeneration biomarkers of BRAVYL in patients with ALS. ...
The authors also tackle the important clinical issues of predicting response and patient outcomes after immunotherapy for cancer using FAUST. Immunotherapies are now important treatments in multiple cancers, however, biomarkers of response to these treatments are lacking in the clinic. FAUST was applied to data from a pivotal Merkel cell ...
December 2022 edition Given the regular posts of peer-reviewed scientific publications on the Medis QFR®, it is clear that this angio-based solution for coronary physiology is extensively used in clinical research and practice. We would like to share these publications with you so that you remain up to date about the research that is ongoing worldwide with this ...
With the emergence of COVID-19, Decentralisation of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. ...
ByClinion
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve ...
With the rising demand for improving patient safety in clinical trials, the adoption of patient-centric solutions is considered the best route to enhance data accuracy and experience automated workflows. ...
ByClinion
We generated a prediction model using 153 samples, with validation using an additional 58 clinical outcome-blinded samples. Gene expression profiles were generated using formalin-fixed, paraffin-embedded tissue samples and microarrays. ...
However, surgeons have been working to develop alternatives to this technique to improve clinical outcomes and the level of patient satisfaction. Natural orifice trans- luminal endoscopic surgery (NOTES) is one such alterna- tive. ...
Various types of liposomes, such as liposomes with different particle sizes, the composition of phospholipids, and suitable additives to meet clinical needs, have been applied in various therapeutics.Protect the drug from degradationThe lipids used in the liposomal formulation are sufficiently resistant to enzymatic degradation to allow the liposomes to protect the encapsulated ...
The key prerequisite for any preservation method is the product stability it can offer for successful clinical outcomes. Expensive and cumbersome preservation methods also contribute significantly to the cost of these technologies and limit the use of cell and gene therapy products. ...
Pathophysiology, treatment options and hot topics Improvements In Stemi Treatment The immediate and long-term prognosis of patients experiencing an ST segment elevation myocardial infarction (STEMI) has changed dramatically since the introduction of coronary reperfusion therapies during primary percutaneous coronary intervention (pPCI). The evolution of these therapies accelerated with the ...
Our aim was to investigate a methylation signature link to clonal evolution in pancreatic tumors that allows us to stratify cellular differences on the origin of the tumor and predict patient prognosis and clinical outcome. Method Using a combination of DNA methylation, transcriptome, and mutation data from TCGA Pancreatic Adenocarcinoma (TCGA-PAAD) set, a total ...
Aligned with the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting theme, Advancing Equitable Cancer Care Through Innovation, Navigating Cancer in collaboration with Texas Oncology, will present key research evaluating the benefits and need for digital health solutions (DHS) across all patient populations. ...