Clinical Trial Studying Articles & Analysis: Older
237 articles found
This ease of use has catalyzed numerous studies aimed at understanding gene function and the mechanisms underlying various diseases. Furthermore, it has led to accelerated timelines for preclinical and clinical trials, ultimately benefiting patients awaiting lifesaving therapies. ...
Brain tumors represent a significant oncology challenge due to their complex genetic profiles and diverse clinical manifestations. To date, scientists have leveraged various therapeutic avenues, including precision medicine, targeted therapies, and immunotherapy. ...
If you’re one of the 45% of American adults who snores at least on an occasional basis, you may get teased about it. Snoring is no joke at all and may a warning sign of an even more serious underlying condition, or sleep apnea. If you’re a sleep apnea victim, your breathing can be interrupted for short periods of time while you sleep. Additionally, not just the snoring individual ...
The prime concern resides in assessing the clinical efficacy of these therapies, as their long-term impact is yet to be conclusively quantified. Hence, an extensive lattice of regulations envelops these modalities, mandating rigorous preclinical studies and clinical trials before their eventual public deployment. ...
GMP growth factors and cytokines designed for therapeutic manufacturing are an essential component of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct contact with patients. In fact, ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
Sialic acid proteins are a special type of glycoproteins, characterized by the presence of sialic acid at the end of the sugar chain. Sialic acid is a biologically important sugar molecule that plays a crucial role in many intercellular interactions, including cell recognition, adhesion and signal transduction. Therefore, the detection of sialic acid proteins holds significant value in disease ...
In epigenomics experiments, the use of parallel samples is to ensure the reliability and repeatability of experimental results. The choice of the number of parallel samples depends on various factors, including experimental design, expected variability, data analysis methods, etc. Here are some specific examples to illustrate the selection of the number of parallel samples in different ...
Elastase is a powerful enzyme that plays a critical role in various biological processes, both in physiological and pathological contexts. It belongs to the family of serine proteases, which are enzymes characterized by a unique serine residue in their active site. This enzyme is known for its ability to degrade elastin, a key protein that provides elasticity and resilience to tissues such as ...
In response to the emerging needs in global healthcare, SOPHiA GENETICS has just revealed the New Generation SOPHiA DDM™ Platform, aiming to stay at the forefront of precision medicine and address today the healthcare needs of tomorrow. ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. This synergistic approach allows for targeted delivery of the cytotoxic agent to cancer cells while sparing healthy tissues, thereby reducing side effects and enhancing therapeutic efficacy. ADC ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
This phase involves laboratory trials and scale-up processes to validate production conditions and parameters. CD Formulation, for example, offers services that assist in process validation and scaling-up from laboratory trials to small batch production. These services also guide equipment selection and operational specifications necessary for subsequent ...
Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...
DIA (Data Independent Acquisition) proteomics sequencing is used for high-throughput, high-sensitivity proteomics analysis. Compared with the traditional DDA (Data Dependent Acquisition) technology, DIA technology can provide a more comprehensive proteome coverage and more reliable quantitative results. DIA technology has a wide range of applications in biomedical research, disease biomarker ...
Understanding Sleep Apnea and Its Types Sleep apnea is a sleep-related breathing disorder that results in poor sleep quality and can lead to daytime fatigue or sleepiness, forgetfulness, and irritability. According to the Mayo Clinic, there are 3 types of sleep apnea to be aware of as follows: OSA or obstructive sleep apnea is the more common form of the disorder and affects roughly 30% of ...
Nowadays, many clinical trials are considered adaptive, meaning that they can change as the trial progresses and that incoming data is used to determine next steps. ...
ByClinion
By targeting specific pathways critical to the growth and survival of the excretory system, the scientists aim to develop more effective and less toxic treatments for brain excretory mechanisms. At the same time, pre-clinical studies are also significant to assess the efficacy and safety of small molecule drugs in brain cancer before they enter ...
In a significant stride towards eradicating a debilitating disease, a new polio vaccine has achieved WHO prequalification. This development represents a crucial milestone in global health, where effective vaccination remains our strongest defence. With a novel design intended to tackle a persistent challenge of the virus, this vaccine is poised to bolster our fight against the spread of ...