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Colorectal Cancer Articles & Analysis
29 articles found
Colorectal cancer is one of the leading causes of cancer-related deaths globally. ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic ...
To begin with, SN38-BSA is composed of SN38, a potent anti-cancer drug, and BSA or Bovine Serum Albumin. SN38 is the active metabolite of the prodrug irinotecan, commonly used in chemotherapy. It's known for its high potency against cancer cells but has limitations in terms of bioavailability and solubility. ...
In recent years, researchers have focused on understanding the functions of CDH1 and its implications in cancer development. This blog post aims to shed light on what CDH1 protein does, its role in cancer, and the future research directions in this field. ...
By inhibiting this enzyme, camptothecin prevents cancer cells from dividing and can induce cell death. Several derivatives of camptothecin, such as irinotecan and topotecan, have been developed and approved for the treatment of various cancers, including colorectal, lung, and ovarian cancers. ...
CADM1 and Ovarian Cancer In ovarian cancer, CADM1 downregulation has been observed in certain subtypes. ...
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. ...
For example, it can serve as an excellent drug carrier using folic acid, especially for targeting colorectal cancer. Polymer-based nanocomposites in combination with oppositely charged polyelectrolytes, such as chitosan/α-lactalbumin and bovine serum albumin/kappa-carrageenan, have been successfully used in the fabrication of edible nanotubes to achieve ...
GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. ...
Challenge Calculating the appropriate sample size for a first of its kind stage-II colon cancer trial As Chairman of the Department of Biostatistics, Professor Satoshi Teramukai leads a variety of investigator-initiated clinical trials at the Kyoto Prefectural University of Medicine. With over 35 years experience, hundreds of published papers and thousands of citations, ...
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An example would be the cell cycle pathway which is going to be involved in many if not all cancers, because cancer is essentially cell replication gone amok. This approach is somewhat similar to the one above because one still references literature supporting the connection between the “related” pathways and the condition. ...
The Role of Mesothelin in Cancer Mesothelin is expressed in many solid tumors, most commonly in mesothelioma, epithelial ovarian and pancreatic cancers, but also in lung and uterine malignancies and in cholangiocarcinomas. ...
In Sun’s research, label-free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes from healthy subjects and lung cancer patients, and potential candidates were discovered as biomarkers for lung cancer. ...
Role of mesothelin in cancer and signaling Mesothelin is expressed in many solid tumors, most commonly in mesothelioma, epithelial ovarian, and pancreatic cancers, as well as in lung and uterine malignancies and bile duct cancer. ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
Abstract We developed a series of models to predict the likelihood of recurrence and the response to chemotherapy for the personalized treatment of stage I and II colorectal cancer patients. A recurrence prediction model was developed from 235 stage I/II patients. ...
Rolled out as part of the Biden-Harris Administration’s Cancer Moonshot, the goal of EOM is to improve the experience of cancer patients, while advancing health equity and increasing access to care, as well as reducing Medicare spending. ...
The researchers expose us to a radically different way of thinking in this article: instead of working on T cells, they focus on changing cancer cell antigens. They employed antibodies to deliver viral antigens to the tumor location and trigger virus-specific T lymphocytes to target cancer cells, destroying them. ...
As cancer-related mutations are cumulatively being identified and characterized, the variety of cancer gene panels is increasing. ...
In the artificial intelligence project, studies are continuing under four main titles: breast cancer, prostate cancer, lung and colorectal cancer. Breast cancer module is a trainable model for identification and scoring of Nottingham grading parameters which are mitosis, nuclear pleomorphism and tubular ...