drug response Articles
-
Lack of robust regulations for generic drugs warning labels leads to outcry
Abstract: An original drug manufacturer seeking new drug approval from the FDA is responsible for accurately and adequately labeling the new drug. A manufacturer of a generic drug is only responsible for making sure its warning label is the same as the reference drug. This has led to an outcry from patients and drug manufacturers as generics makers cannot be held legally responsible for any ...
-
Testing of a drug panel for effects on the gut microbiome using RapidAIM
MedBiome’s founders reported in Microbiome the development of the RapidAIM platform to screen compounds against individual microbiomes in vitro. They tested 43 compounds (including 4 antibiotics) against 5 individual microbiomes using the RapidAIM technology. The RapidAIM workflow provides insights into microbiome absolute abundance and functional responses to ...
-
Applications of Single-Cell RNA Sequencing in Drug Discovery and Development
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. This knowledge enhances our understanding of ...
By CD Genomics
-
Single-Cell RNA Sequencing in Drug Discovery and Development
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better understanding ...
By CD Genomics
-
Drug adherence in Parkinson`s disease
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor ...
By Sensidose AB
-
Understanding the Workflow and Practical Applications of Drug Affinity Responsive Target Stability (DARTS)
Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by proteases ...
-
CD Genomics Perspective: RNA Sequencing, A Powerful Method for Studying Various Diseases
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
By CD Genomics
-
Differential Gene Expression (DGE) Analysis in RNA Sequencing
What Are DEGs in Genetics? DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules. When studying gene ...
By CD Genomics
-
Genetic Link to Parkinson`s Disease Is Best Hope for the Future in Rare Disease
Collaboration Announced Between Researchers at University of California Irvine and Population Diagnostics, Inc. at Rare Disease Event in Southern California The Spooner Girls Foundation , University of California, Irvine School of Medicine, (UCI) and Population Diagnostics, Inc. (PDx), announced today a collaborative research initiative focused on the NUBPL gene at the Spooner family’s ...
-
Analysis of Differential Gene Expression (DGE) in RNA Sequencing
What are Differentially Expressed Genes (DEGs) in Genetics? Differentially Expressed Genes (DEGs) are genes that exhibit significant differences in expression levels between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process through which the information encoded in a gene's DNA sequence is transformed into functional proteins ...
By CD Genomics
-
The Relationship Between the Gut Microbiome and Drugs Is Greater Than We Thought
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from ...
By CD Genomics
-
Microneedle Patch Technologies: Innovations in Drug Delivery
Microneedle patch technologies have revolutionized the field of drug delivery, offering a wide range of advantages over traditional methods. These innovative patches provide a minimally invasive and painless alternative to injections while ensuring precise and controlled drug administration. In this article, we will explore various types of microneedle patch technologies, including ...
-
Establishment of a Stable Organoid Culture System: Customization and Standardization
Prefix Organoids are miniature organs created in vitro from adult stem cells (ASCs) or pluripotent stem cells (PSCs). They form three-dimensional (3D) tissue-like structures through the self-organization, self-renewal, and differentiation capabilities of stem cells. Compared to traditional two-dimensional (2D) cell cultures or spheroids, organoids closely resemble living organs in terms of ...
-
Drug Discovery: Unraveling the Mysteries of Therapeutic Agents
In the vast and ever-evolving field of medicine, the discovery of new drugs has been a critical pursuit, offering hope and relief to countless individuals suffering from various ailments. The process of drug discovery is a complex and multifaceted endeavor, involving the integration of diverse scientific disciplines, including biology, chemistry, and computational science. At the heart of this ...
-
Active pharmaceutical ingredients in wastewater: who are the major contributors?
Active pharmaceutical ingredients (APIs) – responsible for the biological activity of drugs – have been widely found in the environment, yet the precise sources and relative importance of emissions via wastewater are not quite clear. This study assessed emissions from three health institutions in Germany – a hospital, a psychiatric hospital, and a nursing home - and found their ...
-
Dubai on the Brain: NeuroVigil’s Philip Low Assembles Dream Team to Launch Modern Neurotechnology Industry; Expands Conglomerate in Montreal, Canada
DUBAI, United Arab Emirates & PALO ALTO, Calif. & MONTREAL--(BUSINESS WIRE)--Neurotechnology Powerhouse NeuroVigil (ranked “Top 10 most innovative companies in health care” by Washington Post and Fast Company) announced at the New Technology & Mental Health Conference keynote during Dubai’s World Expo that it has recruited senior captains of industry, government and ...
-
What Revisions Has U.S. Pharmacopoeia Made to Pharmaceutical Excipients?
Pharmaceutical excipients are natural or synthetic substances formulated together with the active ingredients of the drug, whose purpose is to increase the formulations containing effective active ingredients or endow the active ingredients in the final dosage form with therapeutic effects, such as promoting drug absorption or solubility. Pharmaceutical excipients can also be used in the ...
-
Researchers Prepared New Tools for the Production of Exosome Drug Carriers
Recently, Yang Hui, a researcher at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, developed a nanofluidic chip technology to achieve high-throughput preparation of exosome drug carriers and experimentally verify the anti-tumor effect of novel exosome drug carriers. Exosomes are nanoscale particles that can be secreted into the extracellular space or body fluids by ...
-
Comparison and Analysis of SMDC, ADC, and DAC
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of ...
By BOC Sciences
-
The Power of Combining Telemetry and Plethysmography
The study of respiratory function and control of breathing is vital for understanding various physiological and pathological conditions. In preclinical research, gaining accurate and reliable data is essential to make meaningful discoveries and develop potential therapies. Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you