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In Vitro Study Articles & Analysis
43 articles found
Abstract Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. Knowledge of these risks has led to a growing interest in cannabis vaporizers, which heat the dry cannabis flower without burning. Vaporizing cannabis still releases ...
The development of recombinant MGP protein has enabled researchers to study the molecular mechanisms of calcification control and evaluate therapeutic interventions in a variety of disease contexts. ...
Traditional investigations of podocytes have faced challenges due to their limited in vitro lifespan. Primary podocyte cultures tend to proliferate for only a brief period, making it difficult to conduct long-term studies on their behavior or response to therapeutic agents. ...
One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. ...
Scientists discovered that platelets can engulf bacteria which opens a new pathway for administering drugs non-invasively using platelets as carriers. Some studies have examined drug delivery systems using platelet endocytosis to absorb fluorescent beads and viral particles which get stored in platelet α-granules for subsequent release during platelet activation. During in ...
Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap between laboratory research and human application. ...
These approaches often include in vitro and in vivo testing, as well as computational modeling. In vitro testing involves studying immune responses in controlled laboratory environments using cell cultures. ...
Preclinical models are indispensable for advancing our knowledge of NAFLD, as they provide the necessary platforms to study its pathophysiology, test potential therapeutics, and explore its progression to more severe forms like non-alcoholic steatohepatitis (NASH). ...
Types of ADME Testing Services To ensure comprehensive evaluation, various testing methodologies are employed, including in vitro and in vivo studies, alongside computational modeling techniques. ...
These studies often involve measuring biomarker levels, which serve as indicators of the biological response. ...
They exhibit high levels of keratinocyte markers, which are essential for maintaining the structural integrity and function of the corneal epithelium. These cells can be cultured in vitro, allowing researchers to study their behavior under controlled conditions. ...
Assessing these properties during drug development can help identify suitable candidates and optimize formulations. The Importance of In Vitro Studies In vitro studies offer a controlled environment to assess drug permeability without the ethical and complexity concerns associated with in vivo studies. ...
Macroautophagy is most extensively studied and best known among the three pathways. When macroautophagy is induced, an isolation membrane encloses a portion of cytoplasm, forming a characteristic double-membraned organelle called the autophagosome. ...
Furthermore, the nanoformulation platform includes in vitro and in vivo testing capabilities to evaluate the efficacy, safety, and stability of the nanoformulations. In vitro studies involve using cell cultures to test the drug release and cytotoxicity, while in vivo studies involve animal models to assess the biodistribution, ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC differentiation to neural stem cells ...
In the vast and intricate world of biology, the development of proteins and antibodies stands as a crucial field of study, driving advancements in medicine, biotechnology, and beyond. From the fundamental building blocks of life to the complex molecules that defend our bodies, these remarkable biomolecules hold the key to unlocking new frontiers in scientific understanding and ...
Furthermore, their ability to infect both immortalized and primary cells significantly broadens their scope of use in vitro and in vivo studies. Concept of Reporter Lentiviral Particles Reporter lentiviral particles carry the technology a step further by including a reporter gene in the viral vector. ...
Although in vivo assays provide more comprehensive information, in vitro DMPK studies are less expensive, have shorter turnaround times, and are considered more ethical as they reduce animal usage in pharmaceutical research. ...
Pooled Human Cryopreserved Hepatocytes In drug development, primary human hepatocytes are the most suitable system for uptake, metabolism, clearance, hepatotoxicity, drug-drug interaction, and other preclinical in vitro studies. We have fresh, cryopreserved, and immortalized lines available. Animal Hepatocytes Primary animal hepatocytes provide a cost-effective ...
Although in vivo assays provide more comprehensive information, in vitro DMPK studies are less expensive, have shorter turnaround times, and are considered more ethical as they reduce animal usage in pharmaceutical research. ...