intestinal barrier Articles
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Applications of Diamine Oxidase
Diamine oxidase (DAO) is an intracellular enzyme that catalyzes diamine in mucosal or ciliated epithelial cells of the mammalian small intestine. It protects the intestinal mucosa by regulating intracellular ion homeostasis, influencing conduction pathways, and promoting cellular repair. Serum DAO is elevated in small intestinal mucosal barrier failure or in intestinal mucosal cell necrosis; ...
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Akkermansia muciniphila - Preclinical studies
A large body of evidence suggests that Akkermansia muciniphila may help protect against specific metabolic disorders and cardiometabolic risk factors associated with a low-grade inflammatory status. Indeed, preclinical studies performed in diet-induced obese mice revealed very interesting beneficial effects linked to the daily oral administration of Akkermansia muciniphila. Giving the ...
By A-Mansia
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A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of ...
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Human Intestinal Ecosystem Analysis
The gut is a complex ecosystem that contains an extremely large community of microbes known as the gut microbiome. The gut microbiome is made up of bacteria, archaea, viruses, fungi, and other eukaryotic microorganisms, including yeasts, flagellates, ciliates, and protozoa. The gut microbiota of a healthy individual consists of six phyla (Firmicutes, Bacteroidetes, Proteobacteria, ...
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Compound Active Probiotics Are Widely Used in the Field of Health
Probiotics are a class of active microorganisms that are beneficial to the host. They are the general term for active beneficial microorganisms that colonize the human intestine and reproductive system and can produce definite health effects to improve the host's micro-ecological balance and play a beneficial role. The beneficial bacteria or fungi in humans and animals mainly include: Clostridium ...
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The Role of Probiotics in Cancer Prevention Receives Increasing Attention
Liver cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths. A healthy diet and lifestyle are the key to preventing various diseases. In recent years, probiotics, as part of a healthy diet, have received increasing attention for their role in cancer prevention and treatment, including liver cancer. Do probiotics have the potential to prevent liver ...
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Increasing the Efficiency of Drug Development with Preclinical Testing Using Human Intestinal Stem Cells
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. However, these studies can be lengthy and expensive and may not accurately recapitulate the behavior of the human gastrointestinal tract. Drugs are thus often developed with undesired gut side effects that are not apparent until clinical trials. Organ-on-a-chip models are the closest ...
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Bile Acid: A Comprehensive Exploration of Function and Metabolism
In the realm of biological sciences, bile acids stand as pivotal molecules, playing a multifaceted role in various physiological processes within organisms. Bile acids are specialized molecules synthesized from cholesterol within the liver. These amphipathic compounds possess a hydrophilic region (carboxylic acid moiety) and a hydrophobic region (steroid backbone). Their distinctive structure ...
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