Kidney Cell Articles & Analysis
16 articles found
Immortalized human podocytes represent a significant advancement in the field of renal research, offering scientists an unprecedented opportunity to study kidney function and pathology. These specialized cells play a crucial role in the filtration barrier of the kidneys, and their immortality allows for extended experimentation beyond the ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. This assay utilizes Madin-Darby Canine Kidney (MDCK) cells, which are a widely used model for studying intestinal absorption and permeability due to their similarity to ...
In the rapidly evolving field of cellular biology and genetic engineering, the development of efficient and reliable cell lines is vital for research and therapeutic applications. One such advancement is the establishment of the Monkey DLL3 stable cell line using HEK293T cells. ...
Types of In Vitro Permeability Assays Various methods are employed in in vitro permeability assays, each suited for different purposes: Caco-2 Cell Model: This assay uses human intestinal epithelial cells, which mimic the intestinal barrier. ...
Clinical trials are the backbone of modern medicine, responsible for bringing innovative, safe, and efficient treatments to market after rigorous testing and evaluation. However, the conventional process of conducting these trials has often been long, expensive, and fraught with inefficiencies¹. The advent of predictive analytics is reshaping the landscape of clinical trials, ushering in a ...
In the present study, we therefore investigated if there is a difference in the dependency of SARS-CoV-2 and IAV on the Raf/MEK/ERK signaling pathway and subsequently on their susceptibility to zapnometinib treatment. 2 Methods2.1 Viruses and cells SARS-CoV-2 (B.1., Isolate “FI”, hCoV-19/Germany/FI1103201/2020) was taken from the strain repository of the Institute ...
Several companies such as Sinovac Biotech Ltd and Sinopharm (Beijing, China) have reported large-scale production of a purified inactivated SARS-CoV-2 virus vaccine in Vero cells that are licensed and widely used in Asian countries. As for vaccines manufactured in Vero cells large manufacturing capabilities are available world-wide, this is an important step to ...
ByNuvonis
Vero cellsare a continuous adherent cell line that is frequently used in cell culture and plays an important role in worldwide vaccine and vector production (manufacturing). ...
ByNuvonis
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
Annotations Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury Inhibition of Gal-3, mediated by MCP, antagonized the pro-apoptotic (cell death) effects. MCP- treated mice demonstrated increased renal function and reduced ...
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
Immortalized cell lines derived from animal models, including intestinal epithelial cells derived from rats (IEC-6 cells) and kidney cells derived from dogs (MDCK cells), have been used to develop in vitro gut models, but have significant limitations for similar reasons as the in vivo models do. ...
Publication Summary: Recent advances in the directed differentiation of human pluripotent stem cells to kidney organoids advances the prospect of drug screening, disease modelling, and even restoration of renal function using patient-derived stem cell lines. Here, we demonstrate the successful adaptation of our directed differentiation protocol ...
San Francisco, CA –Aelan Cell Technologies, with an international research team, today released a study that reveals that age is a key determining factor in the efficacy of cell-based or pharmacological treatments. The study, published in the advanced online publication of Oncotarget: Gerotarget (Focus on Aging) focused on the effect of age on the interaction of Interleukin-2 (IL-2) ...
Adhesion and viability of various cell types on large–scale gold nanopillar electrodes to improve cell–electrode coupling were investigated. Cardiac muscle and human embryonic kidney cells survived and adhered well on gold nanopillars. The muscle cells even protruded into inter–pillar cavities with diameters ...
Sodium azide is a highly toxic substance. However, the mechanism of its toxicity has not been fully established. In the present study, we attempted to investigate the toxicity of sodium azide in various cultured fetal cells, using changes in cellular respiration as an indicator of metabolic inhibition to elucidate tissue-specificity. The human fetal cell lines used in this study included ...