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Necrosis Factor Articles & Analysis

27 articles found

Project - Effects of Apple Pomace-Derived Pectin on the Innate Immune Responses

Project - Effects of Apple Pomace-Derived Pectin on the Innate Immune Responses

Simple Summary The present study investigated possible administration of pectin derived from apple pomace as a beneficial and cost-effective feed additive to be used in trout culture. To achieve the aim, a range of parameters were measured including immune parameters (both at physiological and molecular levels), growth performance and digestive enzyme activity. The results showed promising ...

ByEmoyeni-Training


Understanding Cytokines: Their Roles, Applications, and Detection   

Understanding Cytokines: Their Roles, Applications, and Detection  

Some of the primary classes include interleukins (IL), interferons (IFN), tumor necrosis factors (TNF), colony-stimulating factors (CSF), chemokines, and growth factors (GF). ...

ByCreative Proteomics


Differentiation and Functions of Th17/Treg Cytokines

Differentiation and Functions of Th17/Treg Cytokines

Th precursor cells are regulated by different cytokines and transcription factors and can differentiate into CD4+ T cell subsets such as Th1, Th2, Th17 and Treg cells. ...

ByCreative Proteomics


Unraveling the Mysteries of TREM1 Protein: A Key Player in Inflammation and Disease

Unraveling the Mysteries of TREM1 Protein: A Key Player in Inflammation and Disease

Upon activation, it potentiates the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), thereby exacerbating the inflammatory cascade. ...

ByCreative BioMart


Nanobodies Definition, Structure, Advantages and Applications

Nanobodies Definition, Structure, Advantages and Applications

Caplacizumab targets von Willebrand factor (vWF), inhibits the interaction between vWF and platelets, and is indicated for acquired thrombotic thrombocytopenic purpura (aTTP) bacilli. Caplacizumab was initially approved for marketing by the EMA in September 2018, and was subsequently approved for marketing by the US FDA, Japan PMDA and other drug regulatory agencies.Ozoralizumab ...

ByBOC Sciences


Antibody-Drug Conjugates: New Strategies of ADC Payloads

Antibody-Drug Conjugates: New Strategies of ADC Payloads

Linker selection is one of the key factors in PDC design. Linkers need to balance stability and release efficiency. ...

ByBOC Sciences


Cytokines: The Master Regulators of Immunity and Inflammation

Cytokines: The Master Regulators of Immunity and Inflammation

They induce an antiviral state in neighboring cells, hindering viral replication. Tumor Necrosis Factors (TNFs): TNFs are potent proinflammatory cytokines that are involved in a variety of immune responses, including inflammation, apoptosis, and cell differentiation. ...

ByCreative BioMart


Cytokines in CAR-T Cell Therapy

Cytokines in CAR-T Cell Therapy

Cytokines, including interleukins, tumor necrosis factor, interferons, chemokines, colony-stimulating factors, growth factors, etc., are involved in the activation, proliferation, differentiation and survival of various immune cells. ...

ByCreative Proteomics


Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2

Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2

The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strategy for development of broad-spectrum antivirals. ...

ByAtriva Therapeutics GmbH


Characteristics and Applications of Luminex Multiplex Technology

Characteristics and Applications of Luminex Multiplex Technology

Luminex multiplex assays is a multi-functional, multi-indicator parallel analysis system that organically integrates color-coded beads, laser technology, applied fluidics, the latest high-speed digital signal processor and computer algorithms to create a high degree of specificity and sensitivity for multi-factor detection. It can be widely used in immunoassay, nucleic acid ...

ByCreative Proteomics


Cytokines: Characteristics, Applications, and Quantitative Analysis

Cytokines: Characteristics, Applications, and Quantitative Analysis

Cytokine Classification Cytokines are categorized into various subtypes, including interleukins (IL), interferons (IFN), tumor necrosis factor (TNF), colony-stimulating factor (CSF), chemokines, and growth factors (GF). ...

ByCreative Proteomics


The Crucial Role of Cytokines in Biomedical Research and Drug Development

The Crucial Role of Cytokines in Biomedical Research and Drug Development

Classification and function Cytokines can be classified into different groups based on their functions, including: interleukin (IL), interferon (IFN), tumor necrosis factor (TNF), colony stimulating factor (CSF), chemokine family, growth factor (GF), and TGF-β family. ...

ByBeta Lifescience


Unraveling the IL-17 Family and its Receptor Complex: Key Players in Immune Responses

Unraveling the IL-17 Family and its Receptor Complex: Key Players in Immune Responses

In a mouse model of skin herpes infection, IL-17C can induce neuronal growth in a manner similar to NGF (nerve growth factor). It has also been reported that in mouse models of psoriasis and atopic dermatitis, the absence of IL-17C significantly reduces the inflammatory response. ...

ByBeta Lifescience


Autoimmune Diseases Targets

Autoimmune Diseases Targets

As the name suggests, TSLP was initially identified in the mouse thymic stromal cell line Z210R, as a factor that promotes the proliferation and development of immature B cells. Subsequently, TSLP was found to function as a co-stimulatory factor for thymic cell proliferation and as a lymphopoietin[1]. Although the homology between human and mouse TSLP is low, ...

ByBeta Lifescience


Cytokine Storms and Viral Infections

Cytokine Storms and Viral Infections

Cytokines are small soluble proteins that are secreted by immune cells and tissue cells to play a regulatory role between cells, including interferon (IFN), interleukin (IL), chemokines, colony-stimulating factors (CSF), tumor necrosis factors (TNF) and so on. Cytokines function in autocrine, paracrine or endocrine forms, and can regulate cell ...

ByCreative Proteomics


Inflammatory Cytokines Profile

Inflammatory Cytokines Profile

Tumor necrosis factor-α (TNF-α) Depending on the cell source and molecular structure, it can be divided into alpha and beta types. ...

ByCreative Proteomics


A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics

A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics

Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. ...

ByAltis Biosystems


What Are the Cytokines?

What Are the Cytokines?

More than 200 types of human cytokines have been identified, which can be generally classified into interleukins, interferons, tumor necrosis factors, colony-stimulating factors, chemokines, growth factors, etc. according to their structure as well as function. ...

ByCreative Proteomics


Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

The incidence rates of ALDs are strongly affected by several risk factors such as the quantity and pattern of alcohol consumption, gender, ethnicity, diet, and host genetic factors (O'Shea et al., 2010, Stickel and Hampe, 2012). ...

ByKoBioLabs


The putative α-1,2-mannosyltransferase AfMnt1 of the opportunistic fungal pathogen aspergillus fumigatus is required for cell wall stability and full virulence

The putative α-1,2-mannosyltransferase AfMnt1 of the opportunistic fungal pathogen aspergillus fumigatus is required for cell wall stability and full virulence

Using a red fluorescence fusion protein, we localized AfMnt1 in compact, brefeldin A-sensitive organelles that most likely represent fungal Golgi equivalents. The tumor necrosis factor alpha response of murine macrophages to hyphae was not affected by the lack of the afmnt1 gene, but the corresponding mutant was attenuated in a mouse model of infection. ...

ByAmerican Society for Microbiology (ASM)

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