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Neurodegenerative Diseases Articles & Analysis
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One notable study published in Nature Neuroscience (2021) demonstrated how CX3CL1-fractalkine signaling influences microglial activity in neurodegenerative diseases like Alzheimer’s. These findings suggest potential avenues for therapeutic intervention targeting neuroinflammation. ...
This is particularly crucial for developing targeted therapies and understanding disease mechanisms, as many neurological disorders exhibit species-specific features that limit translatability. Applications in Research HA-c can be employed in various research applications, including: Disease Modeling: By exposing HA-c to pathogenic factors or genetic ...
This groundbreaking approach unlocks new potential in targeting previously “undruggable” proteins, paving the way for transformative therapies in various diseases. At the forefront of this innovation are specialized PROTAC discovery and screening services, which streamline the pathway from concept to clinical application. ...
They have applications in basic biology research, as well as in fundamental processes for drug discovery, disease modeling, regenerative medicine, and personalized treatment approaches. ...
This approach is especially beneficial for investigating diseases with immune dysregulation, such as cancer, autoimmune disorders, or infectious diseases, where multiple cytokines orchestrate pathological processes. ...
Moreover, lipidomic shifts can also reveal insights into metabolic conditions such as obesity, diabetes, and neurodegenerative diseases. For instance, certain lipid species found in exosomes may indicate disrupted signaling pathways or abnormal cellular function, providing opportunities for therapeutic intervention. Metabolomics in Exosome Function and ...
These projects involve a variety of disease targets, including cancer, inflammation, and neurodegenerative diseases. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. ...
This characteristic is being explored in the treatment of conditions such as osteoarthritis, cardiovascular diseases, and neurodegenerative disorders. Immunomodulation: These cells exhibit immunomodulatory properties, which means they can influence the immune response. ...
Observing such differential expression is crucial for understanding cellular physiology and disease mechanisms. For example, some proteins may be upregulated or downregulated in health and disease states, or between normal and treated cells.Detection MethodsThe most commonly used technique is mass spectrometry, particularly liquid chromatography-tandem mass ...
Signal Transduction ResearchBy detecting the phosphorylation level of specific proteins, the intracellular signal transduction pathways can be studied.2. Disease Mechanism ResearchProtein phosphorylation plays crucial roles in many diseases, including cancer, neurodegenerative diseases, and cardiovascular ...
Acetylation is a common post-translational modification of proteins, typically occurring on lysine residues of proteins, and plays a crucial role in regulating protein function, cell signaling, gene expression, and disease onset. For instance, the acetylation state of histones directly influences chromatin structure and the regulation of gene expression.Acetylation detection ...
Bioenergetics ResearchUnderstand the basic principles of cellular energy metabolism.2. Disease MechanismsStudy changes in oxidative phosphorylation in various diseases (such as neurodegenerative diseases, cancer).3. ...
Among them, glycoproteins are an essential biomarker that plays a key role in many biological processes, including disease onset, progression, and treatment response. The Tandem Affinity Purification (TAP) of glycoprotein is an efficient detection method.What Is a ...
Furthermore, changes in the mitochondrial proteome may be associated with certain diseases, including neurodegenerative diseases, cancer, heart disease, diabetes, and genetic disorders.Methods of Mitochondrial Protein SequencingMitochondrial protein sequencing typically involves the following steps: firstly, scientists need to ...
But when the time is right, it can hit the brakes on this growth, ensuring everything stays balanced and healthy. TNC Protein's Role in Disease Like many proteins, when TNC protein goes awry, disease can result. ...
Autophagy has also been implicated in pathological conditions including neurodegenerative diseases, cancer, and inflammatory diseases. Modulation of autophagy has become a potential therapeutic target in human diseases. ...
Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is ...
In post-translational modification (PTM) of proteins, ubiquitination is considered one of the most critical processes in regulating cellular functions and various diseases. The identification of ubiquitination sites becomes very crucial for understanding the mechanisms of ubiquitination-related biological processes. ...
These methods have improved the sensitivity and specificity of ubiquitination event detection, allowing researchers to thoroughly analyze the role of ubiquitination in diseases and cellular processes. Western Blotting This is one of the most commonly used detection methods. ...