Renal Disease Articles & Analysis
38 articles found
Introduction The BALB/C mouse is a widely used inbred strain in biomedical research, particularly in the fields of immunology, cancer research, and genetics. Among the various tissues studied, the kidney holds significant importance due to its complex structure and multifaceted role in physiological functions. A formalin-fixed paraffin-embedded (FFPE) block of the BALB/C mouse kidney serves as an ...
Matrix Gla Protein (MGP) is a small, vitamin K-dependent extracellular matrix protein that plays a critical role in the regulation of vascular calcification and bone development. As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study ...
Dysfunction of podocytes is linked to various kidney diseases, including diabetic nephropathy, focal segmental glomerulosclerosis, and minimal change disease. ...
The Role of Podocytes in Kidney Disease Recent research has highlighted the importance of podocytes in various renal pathologies. ...
The study of cardiovascular biology is essential for understanding the mechanisms that regulate heart function and vascular health. As cardiovascular diseases remain the leading cause of death worldwide, advancements in this field offer crucial insights for developing new treatments and preventive strategies. Understanding the Cardiovascular System The cardiovascular system comprises the heart, ...
Collagen is the most abundant protein in tissues and organs, and glycated collagen refers to collagen modified by glycosylation. Glycated collagen mainly exists in various tissues in the human body, especially those rich in collagen, such as skin, bones, joints, blood vessels, and other connective tissues.Under normal physiological conditions, glycation occurs as a natural biochemical process, ...
Understanding Sleep Apnea and Its Types Sleep apnea is a sleep-related breathing disorder that results in poor sleep quality and can lead to daytime fatigue or sleepiness, forgetfulness, and irritability. According to the Mayo Clinic, there are 3 types of sleep apnea to be aware of as follows: OSA or obstructive sleep apnea is the more common form of the disorder and affects roughly 30% of ...
Structure of Matrix Metalloproteinase (MMP) Family In vertebrates, the MMP family consists of 28 members, at least 23 of which are expressed in human tissues, 14 of which are expressed in the vascular system. MMPs are usually classified into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs based on their substrates and the organization of their ...
PEG modification can increase particle size, shield negative charge, and reduce cytotoxicity, thus avoiding nuclease degradation and renal clearance of siRNA in vivo as well as reducing toxicity in vivo. ...
For patients with previous cardiovascular disease, the risk of myocardial infarction was also significantly reduced. 3. ...
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
Pushers are novel descending aorta rotary pumps that directly increase renal artery pressure. Pullers reduce central venous pressures or renal venous pressures to increase renal perfusion. ...
Muscle loss / muscle wasting is the condition in which, proteolytic systems for protein degradation are activated, while protein synthesis decreases, thereby resulting in muscle fiber shrinkage. This condition may be due age or might be due some chronic conditions like Diabetes mellitus (DM) or chronic kidney disease (CKD). Extreme muscle wasting often results in weight loss. Such a condition is ...
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. Every day new research is making the link stronger. Periodontal infection is the advanced stages of gum disease that causes bone loss. The bone loss is irreversible. Gingivitis is the early stage of gum disease and with early ...
Each year, more than 100,000 new end stage renal disease patients begin therapy on hemodialysis [1]. Native arteriovenous fistulas have recently been the first choice for access, but even with the best surgical care, fistula prevalence is only 47% in the USA [2]. ...
Consequently, bacterial infection is the second leading cause of death in hemodialysis patients with end-stage renal disease.10 Gram-positive Staphylococcus aureus is responsible for the majority of vascular access infections4,11 and subsequently linked to higher rates of patient mortality from serious medical complications including infective endocarditis and ...
Mice kidney samples are used to study renal biology covering topics such as acute kidney injury to chronic kidney disease, both of which are extremely useful for better understanding renal failure in humans. ...
When mRNA is produced from a mutated gene or when the body produces too much of a certain mRNA, it affects the production of its corresponding protein, which can cause adverse effects and/or disease. Complement was discovered in 1890 by the Belgian immunologist Bordet, and it aided and complemented specific antibodies to kill microorganisms, hence the name Complement. ...
In medicine, taking a holistic approach means treating the whole person - body, mind, spirit, and emotions - to achieve one’s optimal health and wellness. For example, if a patient comes in with a sharp, jabbing pain in his hand - a symptom of peripheral neuropathy - a holistic treatment plan may not only include pain relief medicine but also address underlying causes of pain. A holistic ...
Diabetes is a chronic health condition that affects how your body turns food into energy. Most of the food you eat is broken down into sugar and released into your bloodstream. When your blood sugar goes up, it signals your pancreas to release insulin. Insulin acts like a key turning on cells with sugar as fuel (energy). Diabetes affects your body’s ability to produce or use that insulin. ...