Tumor Cells Articles & Analysis: Older
234 articles found
Gene editing has emerged as a transformative tool in the field of biomedical science, with significant implications for the treatment of various diseases. The primary focus is on harnessing this technology for modifying primary T cells, a type of white blood cell crucial for the immune response. This approach has opened new avenues for immunotherapy, providing hope for treating conditions like ...
These models allow researchers to mimic the tumor microenvironment, providing insights into the behavior of cancer cells, their interactions with surrounding tissues, and their responses to various therapeutic agents. ...
Bladder cancer, characterized by the uncontrolled proliferation of abnormal cells within the bladder lining, poses significant treatment challenges due to its potential to invade surrounding tissues and surrounding propensity for recurrence. ...
Changes in the glycosylation patterns of proteins and lipids are known to play a significant role in tumor progression and pathogen-host interactions. By analyzing glycan expression profiles, researchers can identify biomarkers that are specific to particular diseases or pathological conditions. For example, cancer cells often display altered glycosylation ...
Mechanism of Action Upon introduction into cells, miRNA mimics enter the RNA-induced silencing complex (RISC), where they bind to complementary mRNA targets. ...
By integrating a reporter gene into the genome of a cell, researchers can create a stable cell line that emits a measurable signal in response to specific stimuli or conditions. ...
It acts like a skilled architect, carefully laying down the blueprint for the mRNA that mirrors the DNA template. In eukaryotic cells, RNA polymerase II is specifically responsible for synthesizing mRNA. ...
However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be achieved in mice and cell culture systems. A wide range of assays can be performed in this model, from target discovery, target validation or toxicology studies to ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Gene delivery in cancer treatment involves the use of viral or non-viral vectors to deliver therapeutic genes into cancer cells. These approaches allow the targeted delivery of genes that can inhibit tumor growth or enhance the immune system's capability to recognize and destroy cancer cells. One promising strategy is to deliver genes that ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
However, at least in recent studies involving yeasts, HEK293 cells, and tumor cells, this appeared to be uncertain, with R2 0.37. ...
Understanding Clonality Analysis Clonality refers to the origin of a cell population from a single 'parent' or progenitor cell through asexual reproduction or division. This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus ...
The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. ...
Tumor cells differ significantly from normal cells in their energy metabolism. ...
They are generally proteins or polysaccharides found on the surface of pathogens, such as viruses, bacteria, or cancer cells. In the environment of cancer, antigens may be specific to tumor cells and are known as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). Antibodies, also known as ...
Compared with traditional cytotoxins, ADCs have the advantages of strong targeting, less toxic side effects, etc. They can accurately target tumor cells, reduce side effects, and improve the therapeutic effect.ADC drugs are mainly composed of monoclonal antibodies, linkers, and small molecule cytotoxins. ...
Cell Analysis for Brain Tumors Cell analysis, particularly at the single-cell level, provides deep insights into the cellular heterogeneity within brain tumors. ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. This synergistic approach allows for targeted delivery of the cytotoxic agent to cancer cells while sparing healthy tissues, thereby reducing side effects and enhancing therapeutic efficacy. ADC ...
The T cell antigen receptor (TCR) is a characteristic marker of T cells, playing a crucial role in the immune system. Each T cell typically expresses a specific TCR, which has a unique structure and sequence that can recognize different antigens, including bacteria, viruses, tumor cells, and other pathogens. ...