Tumor Response Articles & Analysis
15 articles found
Cancer Treatment: By delivering genes that can induce cancer cell death or enhance the immune response against tumors, adenoviruses are part of innovative approaches in oncology. ...
Through this project, the POAI active machine learning technology constructed a predictive model of tumor sample response to NPDC’s targeted drugs in a highly efficient manner, saving approximately 18 months of wet lab work in the process. Several NPDC compounds demonstrated efficacy across multiple tumor types and are now well positioned ...
Circulating Tumor Cells, or CTCs, are cancer cells that have shed from the primary tumor and enter the bloodstream, where they can travel and potentially lead to metastasis. ...
These conventional models frequently provided misleading results, leading to high failure rates in clinical trials. In response, researchers have developed comprehensive disease models that incorporate multiple biological components, enabling a more holistic understanding of disease mechanisms and therapeutic responses. ...
Alfa Cytology’s Ovarian Cancer Therapy Development Services aim to bridge this gap by offering highly customized, robust therapeutic solutions that correspond with ovarian tumors’ unique biological and molecular characteristics. These services include developing targeted therapies, immunotherapy, and inhibitors and drugs. ...
Researchers use these models because they retain many of the biological properties of the original tumors, thus providing insights into the cancer’s behavior. The establishment of cell lines involves extracting cancer cells from a tumor biopsy, followed by their growth in a nutrient-rich medium under sterile conditions. ...
However, traditional liposomes still have shortcomings such as unsatisfactory targeting distribution characteristics and poor stability, which limit their application in tumor chemotherapy. pH-responsive liposomes pH-sensitive liposomes are destroyed in the acidic environment of the tumor, thereby tending to release antineoplastic drugs to the ...
NIR-PIT drugs can form a new targeted anti-tumor platform that irradiates infrared light to the tumor site through the device. ...
High internalization is not necessarily beneficial to the treatment of solid tumors, because the rapid degradation of ADCs limits their ability to penetrate tumor masses. ...
Based on observations, the researchers used several preclinical models to assess the effect of IL-6 blockade on autoimmune and anti-ctla-4 therapeutic responses. The combination of an IL-6 blocker with an immune checkpoint inhibitor reduced experimental autoimmune encephalomyelitis (EAE) symptoms and improved tumor control, suggesting that the combination ...
Simply put, CAR-T is to transform the patient's immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells. ...
Researchers at the Children's Hospital of Philadelphia (CHOP) have made a breakthrough in the treatment of aggressive solid cancers, and they have developed a new cancer treatment that targets proteins within tumor cells that are essential for tumor growth and survival, but this has not been possible before. Using the power of large data and advanced ...
It is reported that repeated intranodal inoculation of mRNA can stimulate T cell responses by tumor-associated antigens, which can improve the patient's progression-free survival. 3. ...
Why do we need new cell contenders in the CAR field? Well, different CAR immune cells have different advantages and sometimes unique challenges or limitations. So, we began our discussion of alternative CAR-cell types with CAR-NK cells due to their current standing as the most popular alternative CAR-based therapy. However, the expansion of CARs to other cell types has already begun and ...
Using a red fluorescence fusion protein, we localized AfMnt1 in compact, brefeldin A-sensitive organelles that most likely represent fungal Golgi equivalents. The tumor necrosis factor alpha response of murine macrophages to hyphae was not affected by the lack of the afmnt1 gene, but the corresponding mutant was attenuated in a mouse model of infection. ...