D-tek s.a. products

Sm/RNP antibodies are directed against the U1 snRNP complex which is composed of Sm and the three polypeptides of the RNP antigen. Anti-Sm/RNP antibodies are very sensitive markers for Sharp Syndrome. Their sensitivity is 100 %.

The anti-SSA antibodies are directed against SSA (Ro), a protein of 60 kD which belongs to small cytoplasmic ribonucloprotein complexes, the hY-RNP complexes also known as Ro/SSA hY-RNA. These autoantibodies are diagnostic markers and classification criteria for Sjögren’s Syndrome. They are also associated with SLE and Subacute Cutaneous Lupus Erythematosus (SCLE) and present in 90 % of patients with Neonatal Lupus Erythematosus (NLE).

Sm antibodies target spliceosome components designated U-snRNP (Uridin-rich small nuclear RiboNucleo-Proteins) that play an important role in mRNA processing. The main Sm antigen is the so-called D1 protein contained in U1, U2, U4, U5 and U6-snRNP. Sm antibodies are diagnostic markers (ACR criterion) for SLE, with very high specificity (99 %) but low sensitivity for the disease.