2 services found
Newcells Biotech Limited Services
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Models of the Nephron Services
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Drug Transporter Interactions & DDI Services
Investigate renal drug transport modalities and drug interactions in vitro. aProximate™ PTCs retain high expression of the relevant transporters involved in drug handling including megalin and cubilin; so are ideal for drug transporter and drug interaction studies of both small and large molecules. Transporters play a major role in the uptake and efflux of drugs across cellular membranes. Drug interactions with transporter proteins are common and ...
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Cross Species Comparison Services
Cross-species comparison of drug handling with near-physiological kidney transporter model. New drug molecules are usually tested in vivo in two preclinical species to gain a more detailed understanding of how they are transported and eliminated through the kidney and also to mitigate risk of renal toxicity in humans. However, these animal models are not always predictive of human responses. To address this problem, robust, comparative in vitro kidney ...