Cross Species Comparison Services
Cross-species comparison of drug handling with near-physiological kidney transporter model. New drug molecules are usually tested in vivo in two preclinical species to gain a more detailed understanding of how they are transported and eliminated through the kidney and also to mitigate risk of renal toxicity in humans. However, these animal models are not always predictive of human responses. To address this problem, robust, comparative in vitro kidney transporter models, such as aProximate™, are powerful tools to compare different species and are much needed to improve in vitro-in vivo extrapolation (IVIVE).
- Apical to Basal (Jab) and Basal to Apical (Jba) flux
- Net transport
- Renal toxicity
- Drug transporter assays
- Drug interactions
- Flux and net flux drug transport
- Intracellular drug and metabolite concentrations
- Kidney toxicity assays
- Renal drug safety evaluation
- aProximate™ kidney proximal tubule cells
Accelerate your lead compound selection by understanding their mode of action in kidney tissue
- Fully differentiated and polarised kidney proximal tubule cells
- High expression of all relevant transporters
- High predictivity of in vivo and clinical outcomes.