Biopsy Articles
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Study of the pathogenic mechanisms of autoimmune myasthenia gravis - Case Study
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
By Inovarion
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Case Study B - Liquid Biopsy
X-ZELL is collaborating with Singapore General Hospital (SGH) and the National University Hospital Singapore (NUH) to explore how X-ZELL single-cell diagnostics may aid in the early detection of clinically significant prostate cancer in whole blood. The prospectively blinded, 400-patient multi-centre study officially commenced in 2020 and will lay the foundation for the launch of a commercially ...
By X-Zell Inc.
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The Power of Digital Pathology: Why Labs Everywhere Should Make the Switch
Pathology as it is practiced today in labs around the world is not all that different from the pathology of the 19th century. The microscope has changed relatively little since then, and Hematoxylin and Eosin (H&E) stained slides remain the bread and butter of the pathologist. Yet it is not for lack of technological development; in recent years, digital pathology whole slide scanners, digital ...
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Adenocarcinomas and Their Often Misleading Symptoms When Dyspepsia Is an Indication of Cancer - Case Study
Medical History Jane is a 40-year-old, married mother of two teenage boys. She teaches at the local elementary school and has been in good health for most of her life. She has no surgical history. Her most severe ailment up to this point has been the flu at age 27. Her students are first-graders; they are often difficult to control. She also experiences the normal stresses of raising ...
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Tips & Tricks to Optimize Your Tissue Processing
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
By Quartzy Inc.
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VLE for Post-Treatment Assessment - Case Study
Patient History This patient was originally referred with nodular esophageal disease that was endoscopically visible at the Castro-Esophageal Junction (CEJ). The area was treated using combination Cryotherapy and Endoscopic Mucosal Resection (EMRJ. (Figures 1-3) Pathology of the EMR sample was positive for Adenocarcinoma (Figure 4) A subsequent surveillance ECD showed the previous EMR site, a ...
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VLE for Identification of Subsquamous Disease - Case Study
Patient History This patient was a 68 year old man referred with short segment Barrett's Esophagus (BE) with intramucosal carcinoma (IMC). At the referring center, previous resection of nodularity revealed Tla adenocarcinoma with negative margins. Subsequent surveillance biopsies yielded IMC, and triggered referral. For the procedures described here, standard endoscopy with the addition of ...
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Decreasing Benign Breast Ultrasound Biopsies: Prospective Use of AI Decision Support
After implementation of AI decision support, the benign biopsy rate decreased from 71.79% to 59.2% while the overall biopsy rate stayed constant. PPV3 increased from 28.2% to 40.8%. Objective To examine the affect of prospective AI decision support (Koios DS Breast) use on breast ultrasound biopsy performance metrics. Materials and Methods Non-identifiable HIPAA compliant data collected ...
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New Findings from Universal DX: Through a Simple Blood Test, Our Body`s Gut Bacteria Can Help Detect Early-stage Colorectal Cancer
Company Presents Data at ESMO Congress Showing Link Between Microbiome Bacteria and Early Colorectal Cancer Detection (September 12, 2022) CAMBRIDGE, MA. - Universal Diagnostics (Universal DX), a bioinformatics and multi-omics company on a mission to transform cancer into a curable disease, today announced the results of a proof of principle study demonstrating that the analysis of microbiome ...
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An independent assessment of AI for prostate cancer detection - Case Study
Yale Medicine, an academic medical center with a high volume of prostate biopsies, conducted a study to determine Paige Prostate’s utility as a prescreening tool for clinical use. A total of 1,876 prostate core biopsy slides were analyzed by Paige Prostate, and only those cores categorized by the AI as “suspicious” or as out of distribution were manually reviewed by Yale ...
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Nanostics Receives CE Mark for its ClarityDX Prostate Test to Detect Clinically Significant Prostate Cancer
Nanostics’ biomarker and machine learning-powered test, ClarityDX Prostate®, received a CE-IVD Mark. A CE-IVD Mark is required for all in vitro diagnostic (IVD) devices to be placed in the European Economic Area, Iceland, Norway, and Liechtenstein and allows Nanostics to market and sell ClarityDX Prostate® in these countries. The ClarityDX Prostate® test provides patients ...
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Nanostics Announces Study Data Supporting ClarityDX Prostate as a Reflex Test to Predict Clinically Significant Prostate Cancer
Real-world data shows that at a 94% sensitivity level for prostate cancer ClarityDX Prostate® is 147% more specific than the PSA test for predicting clinically significant prostate cancer. Using ClarityDX Prostate® as a reflex test vs. PSA test alone could have resulted in 37% fewer unnecessary biopsies. The clinical study recruited men from two sites in Alberta, Canada, and one site ...
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INOVIQ study validates the use of SubB2M as an aid in diagnosing malignant melanoma
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. SubB2M-based immunohistochemistry applications represent a new product opportunity for SubB2M in the $1.9b immunohistochemistry market. INOVIQ Ltd (ASX:IIQ) has successfully completed ...
By INOVIQ Ltd
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What dermatologists need to know about Bartonella
Galaxy Diagnostics co-founder Dr. Ed Breitschwerdt on ReachMD with Dr. Michael Greenberg on what dermatologists should know about Bartonella species infections. Research over the past 30 years has shown that Bartonella species infect a wide array of cell types, including red blood cells and endothelial cells (in particular cells that line the blood vessels), in both people and ...
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Nanostics Announces the Launch of its Bladder Cancer Clinical Study Identifying Disease Predictors for Early Detection of Bladder Cancer
Clinical study launched in June 2022 with patient recruitment in Alberta with plans to expand to further sites across North America. The aim of the study is to validate a novel and minimally invasive liquid biopsy test for bladder cancer diagnosis using Nanostics’ ClarityDX® diagnostic platform. The study is supported in part by the Alberta Innovates AICE-Concepts Program with a ...
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What is Total Parenteral Nutrition (TPN)
For patients and parents recently affected by or managing short bowel syndrome, TPN is likely new to their vocabulary. While any clinical acronym may sound overwhelming, TPN is not such a complicated one to understand. ...
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Assessment of a urinary TRUS/biomarker-based risk score as inclusion criteria for multiparametric MRI to detect clinically significant prostate cancer
BACKGROUND Non-invasive techniques like urinary biomarkers and multiparametric Magnetic Resonance Imaging (mpMRI) show great promise for the detection of clinically significant prostate cancer (PCa), leading to a reduction of over-diagnosis and over-treatment. Apart from yet to be established diagnostic accuracy is the systematic use of mpMRI challenging due to the high cost of setting up, ...
By MDxHealth
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Interventional Systems Successfully Proves Feasibility of MR-Compatible Robot
Interventional Systems finished the implementation of the IraSME project “E-GantryMate: Compact MR-compatible device for MRI-guided percutaneous needle interventions”. The project kick-off meeting took place in October 2019 at the company’s office in Wattens, Austria. It aimed at expanding and motorizing the MR-compatible manual targeting device previously developed by INS ...
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Validation of a two-gene mRNA urine test for detection of high-grade prostate cancer in German men.
Organizations Martini-Klinik Prostate Cancer Center and Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, MDxHealth, B.V., Nijmegen, Netherlands, MDxHealth, Inc., Irvine, CA, Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium, Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany Abstract ...
By MDxHealth
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Micromate™ Case Report: Robot-Guided Bone Biopsy
Micromate™ Case Report series presents real cases performed by the physicians currently using our full-fledged robotic platform for percutaneous procedures. Today, we join Dr. Alexander Kupferthaler, Interventional Radiologist at the Ordensklinikum Linz – Barmherzige Schwestern, for a robot-guided bone biopsy. Clinical Context 65-year-old female with invasive lobular carcinoma of ...
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