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Medical Specialties Equipment & Supplies Near Canada Prince Edward Island
782 equipment items found
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor[1][2]. 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
3-Deazaneplanocin A hydrochloride (DZNep hydrochloride) is a potent histone methyltransferase EZH2 inhibitor[1][2]. 3-Deazaneplanocin A hydrochlorideis a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[6]. 3-Deazaneplanocin A hydrochloride also has anti-orthopoxvirus and anti-variola ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
GSK-7975A is a potent and orally available CRAC channel ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has the potential for the study of advanced or metastatic solid ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, ...
Manufactured by:MedChemExpress LLC (MCE)Â Â based inMonmouth Junction, NEW JERSEY (USA)
Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC50 of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension ...