Creative Biogene Medical Specialties Services Near Italy
26 services found
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Creative Biogene has developed a series of Cas9 expressing stable cell lines. The Cas9 encoding gene is stably integrated into either random site, or AAVS1 safe harbor site of human genome, or ROSA26 safe harbor site of mouse genome. Apart from HEK293 and HeLa cells, we have achieved Cas9 stable expression in several types of cancer cells which makes it convenient for scientists to study related ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Mitochondria are the primary source of energy for hepatocytes and play a major role in extensive oxidative metabolism and normal liver function. This critical role also designates mitochondria as a gateway function at the center of signaling pathways mediating hepatocyte injury, as impaired mitochondrial function can affect cell survival and contribute to the development and persistence of liver ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Mitochondrial dysfunction causes changes in a variety of biochemical indicators in the body. It is important to understand the body's acid-base system, kidney and liver function, and nutritional parameters. Creative Biogene provides an accurate Metabolic Panel assay service to precisely evaluate the metabolism changes induced by mitochondria ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
The blood levels of different amino acids vary significantly in mitochondrial dysfunctional organisms, especially alanine and branched-chain amino acids (BCAAs). Creative Biogene provides accurate plasma amino acid testing services to precisely evaluate the metabolism changes induced by mitochondria ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Creative Biogene's platform uses the Seahorse XF analyzer to measure external proton flux and OCR oxygen consumption rate (OCR). It can be used to detect metabolic function in real-time. Glycolysis rate assay uses OCR and ECAR to determine mitochondrial acidification, thereby glycolysis proton release rate and biological energy metabolism spectrum of live cells help understand the early stage of ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. Besides the direct oncolytic activity, OVs are also effective in stimulating the body immune responses which can further help recogonize, control or destroy cancer cells. Through the combination of the tumor-specific ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Gamma-retrovirus (γ-retrovirus) is a genus in the Retroviridae family. Two types of γ-retroviruses are widely used in gene therapy which include MoMLV (Moloney Murine Leukemia Virus) and MSCV (Murine Stem Cell Virus). γ-retroviruses can only transduce dividing cells and can promote the efficient transfer of genes into a variety of cell types. The retroviral products are available from Creative ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Autophagy is a catabolic mechanism which sequesters cytoplasmic components for lysosomal-mediated degradation, including protein inclusions and damaged organelles. Autophagy has an important role in diverse physiological processes such as adaptation to nutrient starvation, cell death, embryonic development, energy metabolism, and antigen presentation, among other events. Moreover, autophagy has ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
GFP Stable Cell Line-SW480 was derived from colon of a 50 year-old male with colorectal adenocarcinoma. SW480 is negative for CSAp (CSAp-) and colon antigen 3 and are positive for keratin by immunoperoxidase staining. There is a G to A mutation in codon 273 of the p53 gene resulting in an Arg to His substitution and a C to T mutation in codon 309 resulting in a Pro to Ser substitution. SW480 ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
GFP Reporter Cell Line-HT1080 is engineered to stably overexpress GFP reporter gene. It is an ideal positive control for use in fluorescence assays. In addition, HT1080 cells form tumors post implantation into immunocompromised mice. The in vivo growth of these tumors can be monitored using optical imaging. ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
CpG oligodeoxynucleotides (CpG ODN) is a synthetic oligodeoxynucleotide, containing unmethylated CpG motifs derived from bacterial DNA, with immunostimulatory activities. Several studies have shown that CpG ODN is able to stimulate cells that express TLR9, initiating an immunomodulatory cascade that culminates in the production of Th1 and proinflammatory cytokines and ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
The kidney is a mitochondria-rich organ with high energy requirements in the body. Abnormalities and dysfunction of renal mitochondria affect several cellular pathways, leading to increased oxidative stress, apoptosis, microvascular loss, and fibrosis, all of which can impair kidney function. Creative Biogene provides a comprehensive range of services and products to assist researchers in ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
MMLV retrovirus has been broadly used for gene transduction in a variety of cells. However, expression of genes mediated by MMLV retrovirus can be repressed in many cell types including embryonic stem (ES), embryonal carcinoma (EC) and hematopoietic stem (HS) cells. The transcriptional repression is mainly caused by DNA methylation. ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Mitochondrial dysfunction is rapidly developing as a key pathological feature of early and persistent lung disease. In particular, mitochondria are emerging as central to the pathological processes and clinical phenotypes associated with a range of lung diseases. Creative Biogene provides a comprehensive range of services and products to assist researchers in lung-disease-related mitochondria ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Special attention should be paid to lactate and pyruvate levels when performing biochemical tests of mitochondria. Creative Biogene provides accurate lactate and pyruvate testing services to precisely evaluate the metabolism changes induced by mitochondria ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
The urine organic acid test is one of the primary means of assessing mitochondrial function by measuring metabolites from digestion, assimilation, metabolism, and ATP production to assess the normalcy of metabolic pathways. When one or more pathways are not functioning properly, organic acids will "overflow" into the urine. Creative Biogene provides accurate urine organic acid testing services to ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Cancer cells have a different metabolism than normal cells, which allows them to survive longer and grow faster. Resistance to apoptosis is a key feature of cancer cells, and given the importance of mitochondria in apoptosis, it is crucial to study the behavior of mitochondria in tumors. Creative Biogene provides a comprehensive range of services and products to assist researchers in ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Creative Biogene has long-standing experience in conducting preclinical zebrafish model studies of cardiovascular disease. We offer consultancy and preclinical zebrafish models of cardiovascular disease including hypertension, arrhythmia, heart failure and atherosclerosis, etc. Similar to other animal models, wild-type zebrafish do not spontaneously develop cardiovascular diseases mimicking the ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
CRISPR/Cas9 technology has been used as a genome-editing tool for multiple cell lines, such as tumor cell line and embryonic stem cell lines. Primary T cell, as an important class of immune cells system, play an extremely important role in immunity system. It holds great potential for therapeutic applications to engineer genome in primary T cells. However, genome engineering in primary T cells is ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Virus-like particles (VLPs) are non-infectious nanoscale structures composed of viral proteins. They can be produced in various systems, functioning as delivery carriers of various bio- and nanomaterials. First identified in 1968, these particles self-assemble from viral structural proteins and are efficiently recognized by the immune system. They can be created experimentally using recombinant ...