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In Vitro Assays Articles & Analysis
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We are proud to introduce Myelotracker®, a peptide-based probe. This unique technology specifically targets lactoferrin, a major protein stored in neutrophil granules, making it possible to visualize and study these immune cells with unmatched precision. Unlike many existing tools, Myelotracker does not activate neutrophils, preserving their natural physiological state and ensuring reliable ...
Introduction We recently sat down with one of our valued customers, Dr Alexis Rossignol (Clean Cells), to discuss his experience with VIPS PRO, our cutting-edge technology designed to streamline and enhance the early stages of cell line development. This interview provides insight into Clean Cells’ quest to automate and increase single-cell seeding while having undisputable proof ...
The scientists at Sirenas have run these samples through cutting edge and proprietary chemical extraction and analytics and tested each one in over 70 in-vitro biological assays relevant to human health. The result is the largest repository of information connecting the unchartered chemistry of marine organisms to applications in human health. ...
BySirenas
To that end, we will integ rate virtual (computer) screening methods and cell-based assays to identify lead compounds that can potentially be optimized to produce a cholesterol lowering drugs. Virtual screening, which requires the availability of atomic resolution 3D structures of the target protein, provides a cost effective way to screen million of compounds to identify just a ...
The proof of concept has been established with 100% killing of malaria parasites in in-vitro assays, and greater than 90% killing of malaria parasites in mRNA-based immunization of non-human primates. ...
AFM28 binds to natural killer (NK) cells and CD123-positive tumor cells and demonstrated the induction of tumor cell killing in vitro and a good tolerability and strong anti-tumor activity in vivo. ...
Featured in the abstract are preclinical data from in vitro and cell-based assays that demonstrate how narazaciclib’s inhibitory profile differentiates it from the FDA-approved CDK4/6 inhibitors palbociclib, ribociclib, and abemaciclib. ...
Creative Proteomics's comprehensive suite of protein analysis services brings together a variety of methods, including amino acid analysis, concentration/yield assays, cell potential and in vitro cell culture, glycosylation assays, post-translational modifications, etc. ...
Obsidian designed genetically engineered IL2-free TILs (cytoTIL15™) to express a regulated form of membrane-bound IL15 for tunable long-term persistence, leading to enhanced persistence and efficacy in vitro and in PDX tumor models. Obsidian previously demonstrated cytoTIL15 exhibited enhanced potency and persistence over conventional TILs in vitro, and ...
Oral presentation highlights: Utilizing Araris' linker technology, an anti-Nectin-4 ADC was generated within 24 hours resulting in highly homogenous and pure ADCs with a DAR of ~ 2 and > 98% monomeric content. In In-vitro assays against target positive cell lines, the Araris ADC demonstrated low nM-range cytotoxicity similar to approved enfortrumab-vedotin ...
Oral presentation highlights: Utilizing Araris’ linker technology, an anti-Nectin-4 ADC was generated within 24 hours resulting in highly homogenous and pure ADCs with a DAR of ~ 2 and > 98% monomeric content. In In-vitro assays against target positive cell lines, the Araris ADC demonstrated low nM-range cytotoxicity similar to approved ...
The translation of previously observed in vitro and in vivo persistence of cytoTIL15 TILs, in the absence of IL2, to superior in vivo anti-tumor efficacy in PDX models supports the potential for increased efficacy of cytoTIL15 therapy over conventional TIL therapy in solid tumor malignancies. ...
There is an intense need for more accurate screening methods during preclinical studies using in vitro assays that more closely mimic in vivo conditions. Currently, only 12% of drugs that begin phase 1 clinical trials move on to eventually receive FDA approval. ...
QN-165, a DNA aptamer, is a broad-based antiviral drug candidate that has exhibited antiviral activity in multiple in vitro assays against different viruses. “We are excited to have reached this important milestone of submitting our first IND application to the FDA on our most advanced therapeutics program. ...
Furthermore, Matrix Plus promoted mature hiPSC-CM electrophysiological function and enabled the in vitro visualization of reentrant arrhythmia responsible for fatal cardiac events in humans. Lastly, and importantly, Matrix Plus enabled high throughput cardiotoxicity screening using mature human cardiomyocytes with validation utilizing reference compounds recommended for the ...
Insilico Medicine will be responsible for early research phase target identification and molecular generation and Taisho will work collaboratively with Insilico in validating the results in various in vitro and in vivo assays. Taisho has the exclusive option to acquire Insilico's co-ownership of the successfully developed programs under agreed payment. ...
The activity of the drug translated from in vitro and cell assays to animal studies, validating the company’s screening approach. ...
If you are scoring comets using image analysis, you will want to be confident that the results you are getting are accurate. Comet Assay IV from Perceptive Instruments has a unique scoring method that has been validated both in-house and by many of the world’s leading pharmaceutical organisations and CROs. As part of the JaCVAM initiative to validate the in vivo and in ...
'So far the biological and protective activities of various flavonoids have been extensively studied in vitro, on cell-based assays,' explains researcher and leading author of the study, Dr Marie-Claire Toufektsian of Joseph Fourier University in Grenoble, France. ...