- Home
- Companies
- MedChemExpress LLC (MCE)
- Products
- MedChemExpress - Model Zalifrelimab - ...
MedChemExpress - Model Zalifrelimab - 2148321-69-9
Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling[1].MCE products for research use only. We do not sell to patients.
Zalifrelimab
MCE China:Zalifrelimab
Brand:MedChemExpress (MCE)
Cat. No.HY-P99514
CAS:2148321-69-9
Synonyms:AGEN1884
Purity:98.28%
Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping:Shipping with dry ice.
Description:Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling.
In Vitro:Zalifrelimab (AGEN1884; 0.1, 1, 10 or 100 μg/mL) potently enhances antigen-specific T cell responsiveness that could be potentiated in combination with other immunomodulatory antibodies. Zalifrelimab combined effectively with PD-1 blockade to elicit a T cell proliferative response in the periphery[2].
In Vivo:Zalifrelimab (AGEN1884; 10 mg/kg; i.v.; on days 1 and 29) is well-tolerated in non-human primates and enhances vaccine-mediated antigen-specific immunity[2].
Species:Human
Isotype:Human IgG1 kappa
Recommend Isotype Controls:Human IgG1 kappa, Isotype Control
Hot selling product:Epalrestat | o-Phenanthroline | Liquiritigenin | Santacruzamate A | Catechin | Stearic acid | Phosphatidylcholines,soya | Livmoniplimab | Fluridone | Clemastine (fumarate)
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References:
[1]. David M O'Malley, et al. Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study. J Clin Oncol. 2022 Mar 1;40(7):762-771. [Content Brief]
[2]. Randi B Gombos, et al. Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. PLoS One. 2018 Apr 4;13(4):e0191926. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。