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Zymeworks Inc
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Zymeworks -Model EFECT -Customize & Optimize Immune Response Cell

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using precise antibody Fc modifications that tailor the antibody-mediated immune response. Get the optimal response. Tailor immune system response for a desired therapeutic effect using the Effector Function Enhancement and Control Technology’s (EFECT™) library of Fc region modifications. The EFECT™ library includes proprietary mutations to the CH2 domain of the antibody`s Fc region to selectively modulate an antibody’s interactions with the Fc-gamma receptors (FcgR) expressed on the surface of immune cells and with a component of the complement pathway (i.e. C1q).

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Tailor therapeutic response by directing the activity of recruited immune cells. 

The EFECT™ platform creates antibody modifications that can:

  • Up-regulate activity to enhance immune function
    Enhance antibody-dependent cellular cytotoxicity (ADCC; NK-cell driven) and antibody-dependent cellular phagocytosis (ADCP; macrophage driven) with EFECT antibody variants that selectively increase binding to the FcgRIIIa and/or FcgRIIa receptors
  • Down-regulate activity to suppress auto-immunity
    Inhibit unwanted antibody-mediated auto-immunity by reducing immune responses of B cells with EFECT antibody variants that selectively increase binding to the FcgRIIb receptors
  • Eliminate cytotoxicity 
    Remove binding to all FcgRs and C1q where effector cell-mediated cytotoxicity is undesirable for therapeutic antibodies.