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Drug Conjugation Equipment Supplied In Europe
20 equipment items found
Manufactured by:Synaffix BV based inOss, NETHERLANDS
Any antibody can be converted into a stably conjugated ADC in just a few days by modifying the native antibody glycan using our highly efficient enzymes and metal-free click chemistry approach. Multiple independent experiments confirm that the native glycan position is likely one of the best for attaching ADC payloads to ...
Manufactured by:Synaffix BV based inOss, NETHERLANDS
GlycoConnect™ replaces the existing antibody glycan with a therapeutic payload. Synaffix has established a simple, yet powerful, clinical-stage platform technology enabling best-in-class ADCs, bispecific antibodies and the targeted delivery of various other therapeutic payloads, all without modifying the antibody ...
Manufactured by:The Menarini Group based inFlorence, ITALY
MEN1309 is an antibody-drug conjugate (ADC) constituted by a fully human IgG1 antibody conjugated through a cleavable linker to a cytotoxic agent (a maytansin derivative, DM4), responsible for its antitumor activity. The target antigen, CD205, is highly expressed in a wide range of both solid and hematological cancer cells. ...
by:CIS Pharma AG based inBubendorf, SWITZERLAND
CIS Pharma develops novel antibody-drug- conjugates (ADCs) based on our proprietary polymer carrier platform. Our polymers serve as carriers that are loaded with cytotoxic drugs, radioisotopes or other active entities. The carrier together with its cargo is conjugated to a target-specific antibody using site-directed linker ...
Manufactured by:Mablink Bioscience based inLyon, FRANCE
Antibody–drug conjugates (ADCs) are a unique class of targeted immuno-oncology therapeutics that combine the tumor-targeting selectivity, stability, and favorable pharmacokinetic profile of monoclonal antibodies, with the potent antitumor activity of cytotoxic drugs. ...
Manufactured by:Catalent, Inc based inSomerset, NEW JERSEY (USA)
Antibody-drug conjugates (ADCs) combine the targeted binding specificity and pharmacological advantages of monoclonal antibodies with the potency advantages of small molecule chemotherapy agents via conjugation with chemical linkers. With 10 approved products and a large and growing list of programs in clinical and pre-clinical development, ADCs ...
Manufactured by:Araris Biotech AG based inAu, Zurich, SWITZERLAND
Araris Biotech AG, a spin-off company from the Paul Scherrer Institute (PSI) and ETH Zurich, is pioneering the development of a novel, proprietary antibody-drug conjugate (ADC)-linker technology. Our linker platform enables payload attachment to ‘off-the-shelf’ antibodies in one step without needing to re-engineer or reduce antibodies, resulting in ...
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Manufactured by:AB Sciex LLC based inFramingham, MASSACHUSETTS (USA)
Biotransformation studies are necessary for both small and large molecule therapeutics. From fast and efficient metabolic stability and soft spot analysis to in-depth, comprehensive identification of metabolites and catabolites in a sample, SCIEX offers an integrated solution to give you confident answers ...
Manufactured by:Navigo Proteins GmbH based inHalle, GERMANY
Navigo Proteins’ Precision Targeting unit leverages its protein engineering expertise to create proprietary Affilin® molecules, harnessed to create optimized, next generation biopharmaceutical drugs in numerous fields of use. Navigo Proteins’ Affilin® platform benefits from the inherent engineerability, stability, safety, and ease of manufacturability. Our ...
by:Genmab A/S based inCopenhagen V, DENMARK
Tisotumab Vedotin is an antibody-drug conjugate (ADC) targeted to tissue factor (TF), a protein involved in tumor signaling and angiogenesis.1 It is composed of Genmab’s human monoclonal antibody (mAb) that binds to TF and Seagen’s ADC technology that utilizes a cleavable linker and the cytotoxic drug monomethyl auristatin E (MMAE).1 ...
Manufactured by:Biosceptre International Limited based inCambridge, UNITED KINGDOM
By exploiting the modular nature of the antibody structure, the same panel of antibody sequences can be used to generate a variety of therapeutic antibody formats including, but not limited to, monoclonal, bispecifics, antibody-drug conjugates (ADCs), and bispecific T-cell engagers (BiTEs) in addition to our CAR-T ...
by:Debiopharm based inLausanne, SWITZERLAND
AbYlink™ is an antibody conjugation technology ideally suited for therapeutic and diagnostic applications. Thanks to AbYlink™, cytotoxic or imaging cargos can be selectively attached to the Fc portion of any IgG without prior modification of the antibody. This technology preserves the original affinity of the antibody to its ...
Manufactured by:Cytes Biotechnologies based inBarcelona, SPAIN
Hepatic non-parenchymal cells (NPCs) represent about 30% of the liver and are specialized cells which interact with hepatocytes for several functions. For this reason, liver co-cultures may increase the sensitivity of liver models for ADME/Tox-related research by recapitulating the complexity of a whole liver. "Mix NPCs" provides a mix of different types of liver cells, including Kupffer cells, ...
Manufactured by:Catalent, Inc based inSomerset, NEW JERSEY (USA)
Catalent Biologics’ drug substance development and manufacturing services leverage advanced technology and proven expertise to help clients meet their biologics drug substance needs. Our development teams collaborate closely with our bioanalytical testing and manufacturing teams to ensure that processes and products are scalable to clinical and commercial scale. Catalent’s cell line ...
Manufactured by:Cytes Biotechnologies based inBarcelona, SPAIN
Hepatic stellate cells (HSC) are also known as perisinusoidal cells and they are located in the space of disses. These cells are the major cell type involved in liver fibrosis in response to liver injury and they play a key role in the homeostasis of liver extracellular matrix, repair, regeneration and fibrosis, and control retinol metabolism, storage and ...
Manufactured by:Catalent, Inc based inSomerset, NEW JERSEY (USA)
GPEx cell line development technology is a proven technology that generates high-performance, highly stable, production cell lines. Virtually any cDNA (mAb and multigenic applications) can be inserted into cells. To date, over 600 different mAb and mAb fusions and over 160+ different recombinant proteins have been produced using the GPEx system, with 160+ clinical trials utilizing therapeutic ...
Manufactured by:ulti med Products (Deutschland) GmbH based inAhrensburg, GERMANY
The Single-Drug-Dip test is a rapid chromatographic immunoassay for the detection of various drugs in human urine. This assay provides only a qualitative, preliminary, analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed anayltical result. Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method. Clinical ...
Manufactured by:ulti med Products (Deutschland) GmbH based inAhrensburg, GERMANY
The ulti med DrugControl Test is a specific arrangement of different lateral flow chromatographic immunoassays for the detection of drugs and cut-off concentrations in human urine. This assay provides only a preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) is ...
Manufactured by:Scancell based inOxford, UNITED KINGDOM
Glycosylation is a post-translational modification that occurs inside the cell and results in the addition of sugar motifs, “glycans”, to proteins and lipids that are, in most cases, destined for the cell surface. These glycan structures form the “glycome” and play an integral role in cell-to-cell and cell-to-matrix interactions through modulation of adhesion and cell ...
Manufactured by:Sartorius AG based inGoettingen, GERMANY
Innovation is at the heart of everything we do. Our proprietary drug delivery technology platform, Veltis®, uses engineered recombinant albumin to enhance albumin’s intrinsic characteristics for optimal therapeutic performance of your ...