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Small Molecule Drug Development With Protein Small Molecule Equipment Supplied In North America
19 equipment items found
Manufactured by:MorphoSys AG based inPlanegg, GERMANY
Peptides are an increasingly important class of drug. As natural ligands to many targets, they can combine agonistic or antagonistic activity with low toxicity risk and can be applied to disease targets, where small molecules or antibody-based drugs cannot be used. However, the number of therapeutic peptide drugs is held back by properties that are inherent to wild-type peptides. Namely, that ...
Manufactured by:Symberix, Inc. based inDurham, NORTH CAROLINA (USA)
Symberix is advancing a portfolio of first-in-class drug candidates for multiple adjunct and monotherapeutic indications. Our discovery platform enables precise targeting of bacteria implicated in intestinal toxicity and gastrointestinal disease. By identifying specific bacterial enzyme targets, we can develop small molecule drugs to block harmful bacterial activity without disrupting the ...
Manufactured by:SomaGenics, Inc. based inSanta Cruz, CALIFORNIA (USA)
RNA interference (RNAi) is a naturally occurring process by which RNA molecules inhibit gene expression either pre- or post-transcriptionally. The discovery of RNAi led to a better understanding of gene regulation and opened the door to exciting new applications in research and therapeutics. The 2006 Nobel price was awarded in recognition of this revolutionary ...
Manufactured by:ApiJect Systems, Corp. based inStamford, CONNECTICUT (USA)
Blow-Fill-Seal (BFS) is a globally-trusted aseptic packaging technology where the pharmaceutical-grade plastic container is made, filled with the liquid drug product, and sealed in a rapid, continuous process. BFS is used around the world to package billions of doses of both large and small molecule sterile drug products annually, including ...
Manufactured by:Symberix, Inc. based inDurham, NORTH CAROLINA (USA)
A microbiome is a collection of microorganisms (and their DNA) that occupy a particular location. The "human microbiome" is composed of trillions of tiny microbes (mostly bacteria) that thrive in our mouth, on our skin, and inside our gut. An individual's gut microbiome is a unique and diverse community of thousands of distinct bacterial species. The vast majority of these bacteria are not ...
Manufactured by:Jericho Sciences, LLC based inDurham (RTP), NORTH CAROLINA (USA)
Jericho is developing a new therapeutic drug for FIV infection in cats, working toward a New Animal Drug Application (NADA) with the FDA. Our ongoing studies indicate that Jericho’s small molecule drug candidate can reduce FIV virus levels in chronically-infected cats for many months in the absence of continuing treatment. Extensive testing also indicates that the drug candidate has a good ...
Manufactured by:Entero Therapeutics, Inc. based inBoca Raton, FLORIDA (USA)
FW-ICI-AC is a niclosamide-based, oral, small molecule anti-inflammatory inhibitor therapy for the treatment of immune checkpoint inhibitor (ICI)-associated colitis and diarrhea in metastatic cancer patients. The PASSPORT clinical trial, a Phase 2a study to determine the safety and potential efficacy of niclosamide in the treatment of ICI-AC, received FDA IND clearance in Q4 ...
by:DEARGEN Inc. based inDaejeon, SOUTH KOREA
Dr. UG is an AI platform for developing new drugs that is based on DEARGEN’s deep learning technology. It specializes in genome data analysis, biomarker prediction, molecule selection and optimization. DEARGEN discovers new disease targets with Dr.UG and further realizes precision medicine by designing small molecules for new ...
by:Lena Biosciences, Inc. based inAtlanta, GEORGIA (US) (USA)
Lena Biosciences offers a robust 3D cell culture system for routine, predictive testing in vitro. SeedEZ is a three-dimensional cell culture scaffold made of randomly oriented, inert glass microfibers. The diameter of microfibers is carefully optimized for long-term cell growth and repeat-dose drug testing. The microfibers are arranged in such a way that creates tiny pores for nutrients, gases, ...
Manufactured by:Entero Therapeutics, Inc. based inBoca Raton, FLORIDA (USA)
FW-UP is a niclosamide-based, oral small molecule anti-inflammatory inhibitor therapy for the treatment of ulcerative proctitis (UP) and ulcerative proctosigmoiditis (UPS). FW-UP is currently being investigated in a Phase 2b clinical trial study to study the safety and potential efficacy of niclosamide in patients with UP and ...
by:Alucent Biomedical Inc. based inSalt Lake City,, UTAH (USA)
The Alucent NVS Vessel Restoration System is designed to create a natural, stent-like scaffold using the body’s own tissue and processes. An all-in-one, integrated procedural system, Alucent NVS combines standard angioplasty techniques with a small molecule drug that when photoactivated, promotes extracellular matrix protein linking inside the vessel ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Succinamic acid is a weak inhibitor for human LL-xylose reductase with an IC50 of 1.45 mM. Succinamic acid can be used as a linker for synthesis of CQ-16 ...
Manufactured by:Siolta Therapeutics based inSan Carlos, CALIFORNIA (USA)
Siolta’s Precision Symbiotics Platform enables rapid LBP development. A platform focused on translating microbiome science into novel therapeutics for a healthier world. Siolta’s patient-centric platform leverages our internal expertise in microbiome data analysis, machine learning, anaerobic microbiology, and translational studies to rationally design and optimize multi-strain live ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 ...
Manufactured by:Juvena Therapeutics, inc. based inRedwood City, CALIFORNIA (USA)
Secreted proteins are a proven class of biologics with tremendous therapeutic potential, as they regulate tissue repair and regeneration, organ development, and immune response to disease. The characteristics of secreted proteins render them a rich pool of drug candidates for chronic and age-related diseases. Our therapeutic approach is to unlock the potential of these proteins, starting with ...
Manufactured by:Qualigen Therapeutics, Inc. based inCarlsbad, CALIFORNIA (USA)
Qualigen licensed the G4 selective transcription inhibitor platform from University College London (UCL) in 2022. The licensed technology comprises lead compound QN-302 (formerly SOP1812) and back-up compounds that target regulatory regions of cancer genes that down-regulate gene expression in multiple cancer pathways. Developed by Dr. Stephen Neidle and his group at UCL, the G4 binding concept ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Chlorzoxazone is a SK-type potassium channel activator. Chlorzoxazone modulates FOXO3 phosphorylation and Aβ. Chlorzoxazone enhances immunosuppression, attenuates vasoconstriction, attenuates cognitive deficits, and improves experimental autoimmune ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 ...
by:Lena Biosciences, Inc. based inAtlanta, GEORGIA (US) (USA)
The POP microphysiological system is a lab technology that combines the 3D cell culturing capabilities of our SeedEZ scaffold with the advanced oxygenation and pH stability of our Blood Substitute within a compact, perfused multi-well insert plate, PerfusionPal. The system is ideally suited for modeling interstitial perfusion that cells in most tissues experience in vivo, and the majority of ...