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T Cell Subtypes From Naive T Cells Equipment Supplied In Usa Washington
25 equipment items found
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology - Multiple ...
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology: Multiple ...
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology: Multiple ...
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology: Non-Hodgkin lymphoma (NHL), Acute lymphoblastic leukemia (ALL), Chronic lymphocytic leukemia ...
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology; Non-Hodgkin lymphoma (NHL), Acute lymphoblastic leukemia (ALL), Chronic lymphocytic leukemia ...
Manufactured by:Universal Cells Inc. based inSeattle, WASHINGTON (USA)
Class I molecules present peptides to CD8+ T cells and are composed of B2M paired with diverse heavy alpha chains. Human cells express two alleles each of three polymorphic HLA class I molecules (A,B and C) that must be matched to recipients, as well as the non-polymorphic HLA-E molecule. Universal Donor Cells do not express free B2M and lack surface expression of HLA-A, B and C. The B2M-HLA-E ...
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology: Non-Hodgkin lymphoma (NHL), Acute lymphoblastic leukemia (ALL), Chronic lymphocytic leukemia ...
Manufactured by:Sana Biotechnology based inSeattle, WASHINGTON (USA)
Oncology: Non-Hodgkin lymphoma (NHL), Acute lymphoblastic leukemia (ALL), Chronic lymphocytic leukemia ...
Manufactured by:Universal Cells Inc. based inSeattle, WASHINGTON (USA)
The HLA Class II molecules DP, DQ and DR present peptides to CD4+ T cells and are composed of polymorphic alpha and beta chains. All Class II molecules are expressed from promoters that require the same set of transcription factors. Mutations in the transcription factors RFX5, RFXANK, RFXAP, or CIITA prevent HLA class II expression and cause Bare Lymphocyte Syndrome. Universal Donor Cells can ...
Manufactured by:Adaptive Biotechnologies based inSeattle, WASHINGTON (USA)
Our TCR-antigen discovery capabilities may inform the design and development of next-generation vaccines. Adaptive has validated hundreds of immunogenic antigens that can be selected to design differentiated vaccines. Our platform is also used to detect and track vaccine-induced antigen-specific T cell responses that correlate with efficacy and safety. Our antigen specificity ...
Manufactured by:Adaptive Biotechnologies based inSeattle, WASHINGTON (USA)
We are currently leveraging our TCR discovery capabilities to enable commercialization of novel therapies by collaborators. In the future, we may explore expanding our end-to-end capabilities for the development of cellular therapies and vaccines. TruTCR is summarized in the figure ...
Manufactured by:SystImmune Inc. based inRedmond, WASHINGTON (USA)
By combining bi-valency with bi-specificity in the tetravalent format, the dual checkpoint molecule utilizes avidity and bi-specificity to improve anti-cancer immune cell function. The specificity enhancement both synergistically enhance and expand the breadth of immune cell activity that is diminished in cancer patients (SEBA). The spatio-temporal control of bi-specificity ensure that ...
Manufactured by:Aptevo Therapeutics based inSeattle, WASHINGTON (USA)
ADAPTIR-FLEX technology extends advantages of ADAPTIR technology to create protein therapeutics with varied specificity and valency and potentially new modes of ...
Manufactured by:Aptevo Therapeutics based inSeattle, WASHINGTON (USA)
Demonstrated ability to produce monospecific and bispecific drug candidates; Leverages IgG1 Fc to form homodimeric bispecific molecules; IgG1-derived Fc can be mutated to ablate effector functions antibody-dependent cellcytotoxicity (ADCC) and complementdependent cytotoxicity (CDC), while maintaining original stability and half-life (confirmed by cell binding, cell function, SPRbased measurements ...
Manufactured by:Aptevo Therapeutics based inSeattle, WASHINGTON (USA)
APVO603 is a dual agonist bispecific antibody employing a novel mechanism of action to simultaneously target 4-1BB (CD137) and OX40 (CD134), both members of the TNF-receptor family. Dual targeting of 4-1BB and OX40 provides synergistic co-stimulation of T cells with the potential to amplify the cytotoxic function of activated T cells and NK cells, potentially leading to more robust anti-tumor ...
by:Cyrus Biotechnology Inc. based inSeattle, WASHINGTON (USA)
Novel IL-2 approaches and technologies are driving innovation in the therapeutic development space. The IL-2 pathway influences critical aspects of both immune stimulation and immune regulation, through the development and expansion of regulatory T cells ...
Manufactured by:SystImmune Inc. based inRedmond, WASHINGTON (USA)
Guidance and Navigation Control (GNC) molecules are multi-specific cell engager proteins. GNC in the oncology therapeutics class bind to cancer cells and to immune cells and stimulate the immune cell cancer killing activity. By design, each GNC molecule is multi-function. In the process of killing, the GNC is designed to educate and empower the T cells to be more effective at killing ...
Manufactured by:Adaptive Biotechnologies based inSeattle, WASHINGTON (USA)
Neutralizing antibodies defend healthy cells by interfering with the biological function of an invading virus. These antibodies may be used therapeutically to treat someone currently fighting the disease and provide passive immunity to people who have recently been exposed to ...
Manufactured by:SystImmune Inc. based inRedmond, WASHINGTON (USA)
Guidance and Navigation Control (GNC) molecules are multi-specific cell engager proteins. GNC in the oncology therapeutics class bind to cancer cells and to immune cells and stimulate the immune cell cancer killing activity. By design, each GNC molecule is multi-function. In the process of killing, the GNC is designed to educate and empower the T cells to be more effective at killing ...
Manufactured by:SystImmune Inc. based inRedmond, WASHINGTON (USA)
Guidance and Navigation Control (GNC) molecules are multi-specific cell engager proteins. GNC in the oncology therapeutics class bind to cancer cells and to immune cells and stimulate the immune cell cancer killing activity. By design, each GNC molecule is multi-function. In the process of killing, the GNC is designed to educate and empower the T cells to be more effective at killing ...