Model aProximate - Proximal Tubule
Kidney proximal tubule cell model for safety/efficacy and transporter studies. aProximate™ is one of the most advanced, near physiological, in vitro, kidney proximal tubule cell (PTC) models. aProximate™ PTCs are derived from fresh human kidney tissue and grown on Transwells® where they remain as a functional polarised cell layer that forms tight junctions. In contrast to other primary and immortalised kidney proximal tubule cells in culture, aProximate™ PTCs retain high expression of the key transporters involved in drug handling including Megalin and Cubilin, which is ideal for drug transporter studies. Studies with aProximate™ can give you a detailed mechanistic understanding of how new drugs are transported and eliminated through the kidney and how they interact with other drugs prescribed to the target patient population to help mitigate risk of renal toxicity.
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Available Analytical Readouts
- Flux and net transport measurements
- Measurement of intracellular drug and metabolite concentrations
- Identification of transporter-mediated drug-drug interactions
- Early renal damage biomarkers
- Cell viability
Details
- 24-well Transwells (transporter assays)
- 96-well Transwells (kidney toxicity assays)
- Assay-ready plates for shipment (Human, 24-well & 96-well)
- aProximate™ - primary kidney proximal tubule cells
- Human
- Mouse
- Rat
- Dog
- Non-human primate (NHP)
aProximate™ Model Highlights
Accelerate your lead compound selection by understanding their mode of action in kidney tissue
- Fully differentiated and polarised kidney proximal tubule cells
- High level of expression of all key renal transporters
- High predictivity of in vivo and clinical outcomes
How to Use aProximate™?
Newcells provides aProximate™ assay-ready plates available for shipment to customers in both Europe and the USA to perform kidney transporter and toxicity studies in-house. Assay-ready plates are currently available in 24-well and 96-well Transwell® format. The model is provided with maintenance medium and user guide with a detailed protocol for recovery of cells upon receipt.
Take advantage of our expertise: with our fast and reliable service, our experts design the experiments with you to answer your questions and give you the results within 2 months. Our bespoke projects are carried out in our state-of-the-art UK facilities.
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